Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma
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Published Version
Date
2018
Authors
Wolsztynski, Eric
O'Sullivan, Finbarr
Keyes, Eimear
O'Sullivan, Janet
Eary, Janet F.
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Photo-optical Instrumentation Engineers (SPIE)
Published Version
Abstract
Intratumoral heterogeneity biomarkers derived from positron emission tomography (PET) imaging with fluorodeoxyglucose (FDG) are of interest for a number of cancers, including sarcoma. A range of radiomic texture variables, adapted from general methodologies for image analysis, has shown promise in the setting. In the context of sarcoma, our group introduced an alternative model-based approach to the measurement of heterogeneity. In this approach, the heterogeneity of a tumor is characterized by the extent to which the 3-D FDG uptake pattern deviates from a simple elliptically contoured structure. By using a nonparametric analysis of the uptake profile obtained from this spatial model, a variable assessing the metabolic gradient of the tumor is developed. The work explores the prognostic potential of this new variable in the context of FDG-PET imaging of sarcoma. A mature clinical series involving 197 patients, 88 of whom have complete time-to-death information, is used. Texture variables based on the imaging data are also evaluated in this series and a range of appropriate machine learning methodologies are then used to explore the complementary prognostic roles for structure and texture variables. We conclude that both texture-based and model-based variables can be combined to achieve enhanced prognostic assessments of outcome for patients with sarcoma based on FDG-PET imaging information.
Description
Keywords
Statistical modeling , Statistical analysis , Neural networks , Positron emission tomography , Model-based design , 3D modeling , Feature selection , Principal component analysis , Tumors
Citation
Wolsztynski, E., O’Sullivan, F., Keyes, E., O’Sullivan, J. and Eary, J. F. (2018) 'Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma', Journal of Medical Imaging, 5(2), 024502 (16pp). doi: 10.1117/1.JMI.5.2.024502
Copyright
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.