Somatostatin receptors as a new active targeting sites for nanoparticles

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dc.contributor.author Abdellatif, Ahmed A. H.
dc.contributor.author Aldalaen, Sa'ed M.
dc.contributor.author Faisal, Waleed
dc.contributor.author Tawfeek, Hesham M.
dc.date.accessioned 2018-09-27T12:08:10Z
dc.date.available 2018-09-27T12:08:10Z
dc.date.issued 2018
dc.identifier.citation Abdellatif, A. A. H., Aldalaen, S. e. M., Faisal, W. and Tawfeek, H. M. (2018) 'Somatostatin receptors as a new active targeting sites for nanoparticles', Saudi Pharmaceutical Journal. pp. 1-9. doi: 10.1016/j.jsps.2018.05.014 en
dc.identifier.startpage 1
dc.identifier.endpage 9
dc.identifier.issn 1319-0164
dc.identifier.issn 2213-7475
dc.identifier.uri http://hdl.handle.net/10468/6920
dc.identifier.doi 10.1016/j.jsps.2018.05.014
dc.description.abstract The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type of interaction would diminish side effects and enhance drug delivery efficacy to the target site. Somatostatin receptors (SSTRs) are one type of G protein-coupled receptors, which could be active targeted for various purposes. There are five SSTRs types (SSTR1-5) which are localized at various organs in the body and spread into different tissues. SSTRs could be considered as a promising target to various nanoparticles which is facilitated when nanoparticles are modified through specific ligand or coating to allow better binding. This review discusses the exploration of SSTRs for active targeting of nanoparticles with certain emphasize on their interaction at the cellular level. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1319016418301154
dc.rights © 2018, Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Active targeting en
dc.subject Somatostatin analogues en
dc.subject Somatostatin receptors en
dc.subject Nanoparticles en
dc.subject Cellular uptake en
dc.title Somatostatin receptors as a new active targeting sites for nanoparticles en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Waleed Faisal, Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 E-mail: w.faisal@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Saudi Pharmaceutical Journal en
dc.internal.IRISemailaddress w.faisal@ucc.ie en


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© 2018, Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Except where otherwise noted, this item's license is described as © 2018, Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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