No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life

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dc.contributor.author Plomgaard, Anne M.
dc.contributor.author Alderliesten, Thomas
dc.contributor.author van Bel, Frank
dc.contributor.author Benders, Manon
dc.contributor.author Claris, Olivier
dc.contributor.author Cordeiro, Malaika
dc.contributor.author Dempsey, Eugene
dc.contributor.author Fumagalli, Monica
dc.contributor.author Gluud, Christian
dc.contributor.author Hyttel-Sorensen, Simon
dc.contributor.author Lemmers, Petra
dc.contributor.author Pellicer, Adelina
dc.contributor.author Pichler, Gerhard
dc.contributor.author Greisen, Gorm
dc.date.accessioned 2018-09-27T12:08:24Z
dc.date.available 2018-09-27T12:08:24Z
dc.date.issued 2018
dc.identifier.citation Plomgaard, A. M., Alderliesten, T., van Bel, F., Benders, M., Claris, O., Cordeiro, M., Dempsey, E., Fumagalli, M., Gluud, C., Hyttel-Sorensen, S., Lemmers, P., Pellicer, A., Pichler, G. and Greisen, G. 'No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life', Acta Paediatrica. pp. 1-7. doi: 10.1111/apa.14463 en
dc.identifier.startpage 1
dc.identifier.endpage 7
dc.identifier.issn 0803-5253
dc.identifier.uri http://hdl.handle.net/10468/6945
dc.identifier.doi 10.1111/apa.14463
dc.description.abstract Aim: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age. Methods: In 2012‐2013, the phase II randomised Safeguarding the Brains of our smallest Children trial compared visible cerebral near‐infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group. Cerebral hy oxia was significantly reduced in the intervention group. We followed up 115 survivors from eight European centres at two years of corrected age, by conducting a medical examination and assessing their neurodevelopment with the Bayley Scales of Infant and Toddler Development, Second or Third Edition, and the parental Ages and Stages Questionnaire (ASQ). Results: There were no differences between the intervention (n = 65) and control (n = 50) groups with regard to the mean mental developmental index (89.6 ± 19.5 versus 88.4 ± 14.7, p = 0.77), ASQ score (215 ± 58 versus 213 ± 58, p = 0.88) and the number of children with moderate‐to‐severe neurodevelopmental impairment (10 versus six, p = 0.58). Conclusions: Cerebral NIRS monitoring was not associated with long‐term benefits or harm with regard to neurodevelopmental outcome at two years of corrected age. en
dc.description.sponsorship Strategiske Forskningsråd (0603-00482B) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley, Blackwell Publishing Ltd en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14463
dc.rights © 2018, the Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. en
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject Ages and stages questionnaire en
dc.subject bayley scales of infant and toddler development en
dc.subject cerebral near‐infrared spectroscopy en
dc.subject extremely preterm infants en
dc.subject neurodevelopment en
dc.title No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eugene Dempsey, Paediatrics & Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.dempsey@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Strategiske Forskningsråd
dc.description.status Peer reviewed en
dc.identifier.journaltitle Acta Paediatrica, International Journal of Paediatrics en
dc.internal.IRISemailaddress g.dempsey@ucc.ie en


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© 2018, the Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Except where otherwise noted, this item's license is described as © 2018, the Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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