Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat

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dc.contributor.author O'Neill, Julie
dc.contributor.author Jasionek, Greg
dc.contributor.author Drummond, Sarah E.
dc.contributor.author Brett, Orla
dc.contributor.author Lucking, Eric F.
dc.contributor.author Abdulla, Mohammed A.
dc.contributor.author O'Halloran, Ken D.
dc.date.accessioned 2019-01-23T12:15:07Z
dc.date.available 2019-01-23T12:15:07Z
dc.date.issued 2019-01-16
dc.identifier.citation O'Neill, J., Jasionek, G., Drummond, S. E., Brett, O., Lucking, E. F., Abdulla, M. A. and O'Halloran, K. D. (2019) 'Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat', American Journal of Physiology - Renal Physiology. doi:10.1152/ajprenal.00254.2018 en
dc.identifier.issn 1931-857X
dc.identifier.issn 1522-1466
dc.identifier.uri http://hdl.handle.net/10468/7350
dc.identifier.doi 10.1152/ajprenal.00254.2018
dc.description.abstract Chronic kidney disease (CKD) occurs in more than 50% of patients with obstructive sleep apnea (OSA). However, the impact of intermittent hypoxia (IH) on renal function and oxygen homeostasis is unclear. Male Sprague Dawley rats were exposed to IH (270 secs at 21% O2; 90 secs hypoxia, 6.5% O2 at nadir) for 4 h (AIH) or to chronic IH (CIH) for 8h/day for 2 weeks. Animals were anesthetized and surgically prepared for the measurement of mean arterial pressure (MAP), and left renal excretory function, renal blood flow (RBF), and renal oxygen tension (PO2). AIH had no effect on MAP (123±14 versus (v) 129±14mmHg, mean±SEM, sham v IH). The CIH group were hypertensive (122±9 v 144±15mmHg, P<0.05). Glomerular filtration rate (GFR) (0.92±0.27 v 1.33±0.33ml/min), RBF (3.8±1.5 v 7.2±2.4ml/min) and transported sodium (TNa) (132±39 v 201±47μmol/min) were increased in the AIH group (all P<0.05). In the CIH group, GFR (1.25±0.28 v 0.86±0.28ml/min, P<0.05) and TNa (160±39 v 120±40μmol/min, P<0.05) were decreased, while RBF (4.13±1.5 v 3.08±1.5ml/min) was not significantly different. Oxygen consumption (QO2) was increased in the AIH group (6.76±2.60 v 13.60±7.77μmol/min, P<0.05), but was not significantly altered in the CIH group (3.97±2.63 v 6.82±3.29μmol/min). Cortical PO2 was not significantly different in the AIH group (46±4 v 46±3mmHg), but was decreased in the CIH group (44±5mmHg v 38±2mmHg, P<0.05). AIH: Renal oxygen homeostasis was preserved through a maintained balance between O2 supply (RBF) and consumption (GFR). CIH: Mismatched TNa and QO2 reflects inefficient O2 utilization and thereby sustained decrease in cortical PO2. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Physiological Society en
dc.rights © 2019, American Journal of Physiology-Renal Physiology. All rights reserved. en
dc.subject Chronic kidney disease en
dc.subject Obstructive sleep apnea en
dc.subject Intermittent hypoxia en
dc.subject Renal function en
dc.subject Oxygen homeostasis en
dc.subject Oxygen tension
dc.subject Renal oxygen consumption
dc.subject Intermittent hypoxia
dc.subject Sodium transport efficiency
dc.title Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ken O'Halloran, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.ohalloran@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-01-16
dc.date.updated 2019-01-23T12:03:36Z
dc.description.version Accepted Version en
dc.internal.rssid 469123891
dc.contributor.funder University College Cork en
dc.description.status Peer reviewed en
dc.identifier.journaltitle American Journal of Physiology - Renal Physiology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress k.ohalloran@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary.


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