Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line

Show simple item record Toulouse, André Collins, Grace C. Sullivan, Aideen M. 2012-11-08T10:25:17Z 2012-11-08T10:25:17Z 2011 2012
dc.identifier.citation Toulouse, A., Collins, G. & Sullivan, A. (2012). 'Neurotrophic Effects of Growth/Differentiation Factor 5 in a Neuronal Cell Line'. Neurotoxicity Research, 21(3):256-265. en
dc.identifier.volume 21 en
dc.identifier.issued 3 en
dc.identifier.startpage 256 en
dc.identifier.endpage 265 en
dc.identifier.issn 1029-8428
dc.identifier.doi 10.1007/s12640-011-9266-7
dc.description.abstract The neurotrophin growth/differentiation factor 5 (GDF5) is studied as a potential therapeutic agent for Parkinson's disease as it is believed to play a role in the development and maintenance of the nigrostriatal system. Progress in understanding the effects of GDF5 on dopaminergic neurones has been hindered by the use of mixed cell populations derived from primary cultures or in vivo experiments, making it difficult to differentiate between direct and indirect effects of GDF5 treatment on neurones. In an attempt to establish an useful model to study the direct neuronal influence of GDF5, we have characterised the effects of GDF5 on a human neuronal cell line, SH-SY5Y. Our results show that GDF5 has the capability to promote neuronal but not dopaminergic differentiation. We also show that it promotes neuronal survival in vitro following a 6-hydroxydopamine insult. Our results show that application of GDF5 to SH-SY5Y cultures induces the SMAD pathway which could potentially be implicated in the intracellular transmission of GDF5 s neurotrophic effects. Overall, our study shows that the SH-SY5Y neuroblastoma cell line provides an excellent neuronal model to study the neurotrophic effects of GDF5. en
dc.description.sponsorship PRTLI3 programme en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer-Verlag en
dc.rights © 2011, Springer-Verlag. The final publication is available at en
dc.subject Growth/differentiation factor 5 en
dc.subject Neurotrophin en
dc.subject 6-hydroxydopamine en
dc.subject SH-SY5Y cells en
dc.subject Parkinson’s disease en
dc.title Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line en
dc.type Article (peer-reviewed) en
dc.internal.authorurl en
dc.internal.authorcontactother André Toulouse, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2012-11-07T09:32:21Z
dc.description.version Accepted Version en
dc.internal.rssid 97976584
dc.contributor.funder Higher Education Authority en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neurotoxicity Research en
dc.internal.copyrightchecked No en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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