• Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions 

  Miguel, Sophie; Champ, Claire; Day, Jon; Aarts, Esther; Bahr, Ben A.; Bakker, Martijntje; Bánáti, Diana; Calabrese, Vittorio; Cederholm, Tommy; Cryan, John; Dye, Louise; Farrimond, Jonathan A.; Korosi, Aniko; Layé, Sophie; Maudsley, Stuart; Milenkovic, Dragan; Mohajeri, M. Hasan; Sijben, John; Solomon, Alina; Spencer, Jeremy P. E.; Thuret, Sandrine; Vanden Berghe, Wim; Vauzour, David; Vellas, Bruno; Wesnes, Keith; Willatts, Peter; Wittenberg, Raphael; Geurts, Lucie (Elsevier Ltd, 2018)

  Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, ...
• Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala 

  O'Loughlin, Elaine; Pakan, Janelle M. P.; Yilmazer-Hanke, Deniz; McDermott, Kieran W. (BioMed Central Ltd., 2017)

  Background: Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of ...
• Visceral pain: role of the microbiome-gut-brain axis 

  Rea, Kieran; O'Mahony, Siobhain; Dinan, Timothy G.; Cryan, John F. (Portland Press, 2017-04)

  A growing body of preclinical and clinical evidence supports a relationship between the complexity and diversity of the microorganisms that inhabit our gut (human gastrointestinal microbiome) and health status. These ...
• The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective 

  Cussotto, Sofia; Sandhu, Kiran V.; Dinan, Timothy G.; Cryan, John F. (Elsevier, 2018-05-10)

  The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, ...
• The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β 

  Ó Léime, Ciarán S.; Hoban, Alan E.; Hueston, Cara M.; Stilling, Roman; Moloney, Gerard; Cryan, John F.; Nolan, Yvonne M. (Elsevier, 2018-03-05)

  TLX is an orphan nuclear receptor highly expressed within neural progenitor cells (NPCs) in the hippocampus where is regulates proliferation. Inflammation has been shown to have negative effects on hippocampal function as ...

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