• Identifying early inflammatory changes in monocyte derived macrophages from a population with IQ discrepant episodic memory 

  Downer, Eric J.; Jones, Raasay S.; McDonald, Claire L.; Greco, Eleonora; Brennan, Sabina; Connor, Thomas J.; Robertson, Ian H.; Lynch, Marina A. (Public Library of Science, 2013)

  Background: Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like ...
• Cationic and PEGylated amphiphilic cyclodextrins: co-formulation opportunities for neuronal siRNA delivery 

  O'Mahony, Aoife M.; Ogier, Julien R.; Darcy, Raphael; Cryan, John F.; O'Driscoll, Caitríona M. (Public Library of Science, 2013)

  Optimising non-viral vectors for neuronal siRNA delivery presents a significant challenge. Here, we investigate a co-formulation, consisting of two amphiphilic cyclodextrins (CDs), one cationic and the other PEGylated, ...
• Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain 

  Carroll, Siobhan Y.; O'Mahony, Siobhain M.; Grenham, Susan; Cryan, John F.; Hyland, Niall P. (Public Library of Science, 2013)

  The interface between psychiatry and stress-related gastrointestinal disorders (GI), such as irritable bowel syndrome (IBS), is well established, with anxiety and depression the most frequently occurring comorbid conditions. ...
• Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice 

  McAllan, Liam; Skuse, Peter; Cotter, Paul D.; O'Connor, Paula M.; Cryan, John F.; Ross, R. Paul; Fitzgerald, Gerald F.; Roche, Helen M.; Nilaweera, Kanishka N. (Public Library of Science, 2014)

  Macronutrient quality and composition are important determinants of energy balance and the gut microbiota. Here, we investigated how changes to protein quality (casein versus whey protein isolate; WPI) and the protein to ...
• Devil's Claw to suppress appetite - ghrelin receptor modulation potential of a Harpagophytum procumbens root extract 

  Torres-Fuentes, Cristina; Theeuwes, Wessel F.; McMullen, Michael K.; McMullen, Anna K.; Dinan, Timothy G.; Cryan, John F.; Schellekens, Harriët (Public Library of Science, 2014)

  Ghrelin is a stomach-derived peptide that has been identified as the only circulating hunger hormone that exerts a potent orexigenic effect via activation of its receptor, the growth hormone secretagogue receptor (GHS-R1a). ...

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