• Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin 

  Walsh, Jacinta; Olavarría-Ramírez, Loreto; Lach, Gilliard; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F.; Griffin, Brendan T.; Hyland, Niall P.; Clarke, Gerard (American Physiological Society, 2020-03-09)

  The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules. Both host and environmental factors may influence ...
• Association between preeclampsia and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study 

  Maher, Gillian M.; Dalman, Christina; O'Keeffe, Gerard W.; Kearney, Patricia M.; McCarthy, Fergus P.; Kenny, Louise C.; Khashan, Ali S. (Wiley, 2020-02-13)

  Objective: Examine the association between preeclampsia and attention deficit hyperactivity disorder (ADHD), using a large Swedish‐based registry cohort. Methods: This study comprised 2,047,619 children, with 114,934 (5.6%) ...
• You've got male: Sex and the microbiota-gut-brain axis across the lifespan 

  Jaggar, Minal; Rea, Kieran; Spichak, Simon; Dinan, Timothy G.; Cryan, John F. (Elsevier Inc., 2019-12-02)

  Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; ...
• Application of a physiologically-based pharmacokinetic model for the prediction of bumetanide plasma and brain concentrations in the neonate 

  Donovan, Maria D.; Abduljalil, Khaled; Cryan, John F.; Boylan, Geraldine B.; Griffin, Brendan T. (Wiley, 2018-01-10)

  Bumetanide is a loop diuretic that is proposed to possess a beneficial effect on disorders of the central nervous system, including neonatal seizures. Therefore, prediction of unbound bumetanide concentrations in the brain ...
• Natural compulsive-like behaviour in the deer mouse (Peromyscus maniculatus bairdii) is associated with altered gut microbiota composition 

  Scheepers, Isabella M.; Cryan, John F.; Bastiaanssen, Thomaz F. S.; Rea, Kieran; Clarke, Gerard; Jaspan, Heather B.; Harvey, Brian H.; Hemmings, Sian M. J.; Santana, Leonard; van der Sluis, Rencia; Malan-Müller, Stefanie; Wolmarans, De Wet (Wiley, 2019-10-29)

  Obsessive–compulsive disorder (OCD) is a psychiatric illness that significantly impacts affected patients and available treatments yield suboptimal therapeutic response. Recently, the role of the gut–brain axis (GBA) in ...

View more