• Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish 

  Borrelli, Luca; Aceto, Serena; Agnisola, Claudio; De Paolo, Sofia; Dipineto, Ludovico; Stilling, Roman M.; Dinan, Timothy G.; Cryan, John F.; Menna, Lucia F. (Nature Publishing Group, 2016-07-15)

  The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication that integrates the gut and central nervous system (CNS) activities. Animal studies reveal that gut bacteria influence behaviour, ...
• Estrous cycle influences excitatory amino acid transport and visceral pain sensitivity in the rat: Effects of early-life stress 

  Moloney, Rachel D.; Sajjad, Jahangir; Foley, Tara; Felice, Valeria D.; Dinan, Timothy G.; Cryan, John F.; O'Mahony, Siobhain M. (BioMed Central, 2016-07-14)

  Background: Early-life stress (ELS) is a recognized risk factor for chronic pain disorders, and females appear to be more sensitive to the negative effects of stress. Moreover, estrous cycle-related fluctuations in estrogen ...
• Obesity takes its toll on visceral pain: High-fat diet induces toll-like receptor 4-dependent visceral hypersensitivity 

  Tramullas, Mónica; Finger, Beate C.; Dinan, Timothy G.; Cryan, John F. (PLoS, 2016-05-09)

  Exposure to high-fat diet induces both, peripheral and central alterations in TLR4 expression. Moreover, functional TLR4 is required for the development of high-fat diet-induced obesity. Recently, central alterations in ...
• Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status 

  Scott, Karen A.; de Kloet, Annette D.; Smeltzer, Michael D.; Krause, Eric G.; Flak, Jonathan N.; Melhorn, Susan J.; Foster, Michelle T.; Tamashiro, Kellie L. K.; Sakai, Randall R. (Elsevier, 2017-03-08)

  Mood disorders such as major depressive disorder (MDD) affect a significant proportion of the population. Although progress has been made in the development of therapeutics, a large number of individuals do not attain full ...
• Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse 

  Scott, Karen A.; Ida, Masayuki; Peterson, Veronica L.; Prenderville, Jack A.; Moloney, Gerard M.; Izumo, Takayuki; Murphy, Kiera; Murphy, Amy; Ross, R. Paul; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F. (Elsevier, 2017-02-04)

  Over the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the ...

View more