• Quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and a-synuclein-induced neurodegeneration 

  Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O'Keeffe, Gerard W. (Springer, 2021-03-12)

  Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular a-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there ...
• Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome 

  Wilmes, Lars; Collins, James M.; O'Riordan, Kenneth J.; O'Mahony, Siobhain M.; Cryan, John F.; Clarke, Gerard (John Wiley & Sons, Inc., 2021-02-13)

  Background: The gastrointestinal microbiota has emerged as a key regulator of gut-brain axis signalling with important implications for neurogastroenterology. There is continuous bidirectional communication between the gut ...
• Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress? 

  Barron, Aaron; McCarthy, Cathal; O'Keeffe, Gerard W. (Springer Nature Switzerland AG, 2021-01-25)

  Preeclampsia (PE) is a common and serious hypertensive disorder of pregnancy that occurs in approximately 3â 5% of first-time pregnancies and is a well-known leading cause of maternal and neonatal mortality and morbidity. ...
• Growth differentiation factor 5 exerts neuroprotection in an a-synuclein rat model of Parkinson's disease 

  Goulding, Susan R.; Concannon, Ruth M.; Morales-Prieto, Noelia; Villalobos-Manriquez, Francisca; Clarke, Gerard; Collins, Louise M.; Lévesque, Martin; Wyatt, Sean L.; Sullivan, Aideen M.; O'Keeffe, Gerard W. (Oxford University Press, 2020-11-30)
• Diet and depression: exploring the biological mechanisms of action 

  Marx, Wolfgang; Lane, Melissa; Hockey, Meghan; Aslam, Hajara; Berk, Michael; Walder, Ken; Borsini, Alessandra; Firth, Joseph; Pariante, Carmine M.; Berding, Kirsten; Cryan, John F.; Clarke, Gerard; Craig, Jeffrey M.; Su, Kuan-Pin; Mischoulon, David; Gomez-Pinilla, Fernando; Foster, Jane A; Cani, Patrice D.; Thuret, Sandrine; Staudacher, Heidi M.; Sánchez-Villegas, Almudena; Arshad, Husnain; Akbaraly, Tasnime; O'Neil, Adrienne; Segasby, Toby; Jacka, Felice N. (Springer Nature Limited, 2020-11-03)

  The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted ...

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