• The association between preeclampsia and childhood development and behavioural outcomes 

  Maher, Gillian M.; O'Keeffe, Gerard W.; O'Keeffe, Linda M.; Matvienko-Sikar, Karen; Dalman, Christina; Kearney, Patricia M.; McCarthy, Fergus P.; Khashan, Ali S. (Springer Nature Switzerland AG, 2020-04-11)

  Objectives: To examine the associations between preeclampsia and longitudinal child developmental and behavioural outcomes using data from a nationally representative study of children living in Ireland. Methods: We used ...
• Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: impact of butyrate and fructo-oligosaccharide-inulin 

  Walsh, Jacinta; Gheorghe, Cassandra E.; Lyte, Joshua M.; van de Wouw, Marcel; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F.; Griffin, Brendan T.; Clarke, Gerard; Hyland, Niall P. (Wiley, 2020-04-26)

  Objectives: Our objective was to demonstrate microbial regulation of hepatic genes implicated in drug metabolism and transport using germ‐free (GF) mice and to explore the impact of a microbial metabolite, butyrate, and a ...
• Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat 

  Donoso, Francisco; Egerton, Sian; Bastiaanssen, Thomaz F. S.; Fitzgerald, Patrick; Gite, Snehal; Fouhy, Fiona; Ross, R. Paul; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F. (Elsevier Ltd., 2020-04-10)

  There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of host behaviour and as therapeutic target for neuropsychiatric disorders. In addition, accumulating evidence suggests that early-life ...
• Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin 

  Walsh, Jacinta; Olavarría-Ramírez, Loreto; Lach, Gilliard; Boehme, Marcus; Dinan, Timothy G.; Cryan, John F.; Griffin, Brendan T.; Hyland, Niall P.; Clarke, Gerard (American Physiological Society, 2020-03-09)

  The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules. Both host and environmental factors may influence ...
• Association between preeclampsia and attention deficit hyperactivity disorder: a population-based and sibling-matched cohort study 

  Maher, Gillian M.; Dalman, Christina; O'Keeffe, Gerard W.; Kearney, Patricia M.; McCarthy, Fergus P.; Kenny, Louise C.; Khashan, Ali S. (Wiley, 2020-02-13)

  Objective: Examine the association between preeclampsia and attention deficit hyperactivity disorder (ADHD), using a large Swedish‐based registry cohort. Methods: This study comprised 2,047,619 children, with 114,934 (5.6%) ...

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