What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review

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dc.contributor.author Kan, Janice M.
dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Ooi, Chee Y.
dc.contributor.author Kasparian, Nadine A.
dc.date.accessioned 2019-02-01T11:23:18Z
dc.date.available 2019-02-01T11:23:18Z
dc.date.issued 2019-01-08
dc.identifier.citation Kan, J. M., Cowan, C. S. M., Ooi, C. Y. and Kasparian, N. A. (2019) 'What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review', Developmental Psychobiology, pp. 1-14. doi:10.1002/dev.21819 en
dc.identifier.startpage 1 en
dc.identifier.endpage 14 en
dc.identifier.issn 0012-1630
dc.identifier.issn 1098-2302
dc.identifier.uri http://hdl.handle.net/10468/7420
dc.identifier.doi 10.1002/dev.21819
dc.description.abstract A deeper understanding of the gut-brain axis is of significance in pediatrics, given the influential role of early childhood experiences and exposures in shaping the microbiome, and health, across the life course. This systematic review synthesized evidence on the connection between the gut microbiome and mental health in children with physical illness. Six electronic databases were systematically searched and data extracted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Of 1,476 identified articles, 11 articles reporting on nine unique studies (all randomized controlled trials) were included. Most studies examined the gut microbiome in infants with colic, while the remaining studies investigated outcomes in children aged 1 day to 18 years at risk for atopic dermatitis or irritable bowel syndrome. Baseline and postintervention gut microbiome differences varied across studies. Findings on psychological functioning also varied, with only half of the captured studies showing a positive effect of intervention on psychological well-being. Only two studies analyzed the association between the gut microbiome and psychological outcomes, each with a different pattern of results. As the field moves forward, it will be critical to gain a better understanding of the microbiome characteristics that influence mental health outcomes in pediatric populations. en
dc.description.sponsorship National Heart Foundation of Australia (Future Leader Fellowship - Grant Number: 101229); National Health and Medical Research Council (Grant Number: APP1081001); Commonwealth Fund (Harkness Fellowship in Health Care Policy & Practice); University of New South Wales and Sydney Partnership for Health, Education, Research and Enterprise (2017 Seed Funding) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.rights © 2019, Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Kan, J. M., Cowan, C. S. M., Ooi, C. Y. and Kasparian, N. A. (2019) 'What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review', Developmental Psychobiology, pp. 1-14. doi:10.1002/dev.21819, which has been published in final form at https://doi.org/10.1002/dev.21819. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. en
dc.subject Childhood en
dc.subject Chronic illness en
dc.subject Mental health en
dc.subject Microbiome en
dc.subject Physical health en
dc.subject Quality of life en
dc.title What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitlin Cowan, Alimentary Pharmabotic Centre (Apc), University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitlin.cowan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-01-08
dc.date.updated 2019-02-01T10:10:14Z
dc.description.version Accepted Version en
dc.internal.rssid 471965856
dc.contributor.funder National Heart Foundation of Australia en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Commonwealth Fund en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder University of New South Wales en
dc.contributor.funder Sydney Partnership for Health, Education, Research and Enterprise
dc.description.status Peer reviewed en
dc.identifier.journaltitle Developmental Psychobiology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMIND en


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