Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats

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dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Callaghan, Bridget L.
dc.contributor.author Richardson, Rick
dc.date.accessioned 2019-02-06T12:53:59Z
dc.date.available 2019-02-06T12:53:59Z
dc.date.issued 2013-10
dc.identifier.citation Cowan, C. S. M., Callaghan, B. L. and Richardson, R. (2013) 'Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats', Behavioral Neuroscience, 127(5), pp. 703-711. doi:10.1037/a0034118 en
dc.identifier.volume 127 en
dc.identifier.issued 5 en
dc.identifier.startpage 703 en
dc.identifier.endpage 711 en
dc.identifier.issn 1939-0084
dc.identifier.uri http://hdl.handle.net/10468/7450
dc.identifier.doi 10.1037/a0034118
dc.description.abstract Recent studies have shown that chronic early life stress results in precocious expression of the adult-like phenotype of fear retention and inhibition. However, it is unknown whether the experience of acute early trauma has the same effects as exposure to chronic early stress. In the present study, a 24-hr period of maternal deprivation on postnatal day (P) 9 was used as an acute early life stressor. In infancy (P16-17), maternally deprived and standard-reared rats were conditioned to fear a noise paired with shock. In Experiments 1 and 2, fear to the noise was then extinguished before rats were tested for context-mediated fear renewal or stress-induced fear reinstatement. In Experiments 3a and 3b, conditioned rats were tested for fear retention 1, 7, or 14 days after training. Whereas standard-reared infants exhibited relapse-resistant extinction and infantile amnesia (i.e., behaviors typical of their age), maternally deprived infants exhibited the renewal and reinstatement effects (i.e., relapse-prone extinction) and showed good retention of fear over the 7- and 14-day intervals (i.e., infantile amnesia was reduced). In other words, similar to rats exposed to chronic early life stress, rats exposed to acute early stress expressed an adult-like profile of fear retention and inhibition during infancy. These findings suggest that similar mechanisms might be involved in the effects of acute and chronic stress on emotional development, and may have implications for our understanding and treatment of emotional disorders associated with early adversity. en
dc.description.sponsorship Petre Foundation (Petre Foundation Scholarship); University of New South Wales (UNSW Research Excellence Award) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Psychological Association en
dc.relation.uri http://dx.doi.org/10.1037/a0034118
dc.rights © American Psychological Association, 2013. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: http://dx.doi.org/10.1037/a0034118 en
dc.subject Maternal deprivation en
dc.subject Stress, psychological en
dc.subject Separation MS en
dc.subject Development en
dc.subject Extinction en
dc.subject Fear conditioning en
dc.subject Infantile amnesia en
dc.subject Maternal deprivation en
dc.title Acute early-life stress results in premature emergence of adult-like fear retention and extinction relapse in infant rats en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitlin Cowan, Alimentary Pharmabotic Centre (APC), University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitlin.cowan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-02-05T16:26:35Z
dc.description.version Accepted Version en
dc.internal.rssid 472455979
dc.internal.pmid 24128359
dc.contributor.funder Australian Research Council en
dc.contributor.funder Petre Foundation en
dc.contributor.funder University of New South Wales en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Behavioral Neuroscience en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitlin.cowan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP0985554/AU/Developmental analysis of extinction of learned fear in rats/ en
dc.relation.project info:eu-repo/grantAgreement/ARC/Discovery Projects/DP120104925/AU/Effects of early life trauma on fear memory and fear extinction in rats/ en


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