Detection and prevention of adverse drug reactions in multi-morbid older patients

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dc.contributor.author Jennings. Emma L. M.
dc.contributor.author Gallagher, Paul F.
dc.contributor.author O'Mahony, Denis
dc.date.accessioned 2019-02-12T11:55:43Z
dc.date.available 2019-02-12T11:55:43Z
dc.date.issued 2018-09-12
dc.identifier.citation Jennings, E., Gallagher, P. and O'Mahony, D. (2018) 'Detection and prevention of adverse drug reactions in multi-morbid older patients', Age and Ageing, 48(1), pp. 10-13. doi: 10.1093/ageing/afy157 en
dc.identifier.volume 48 en
dc.identifier.issued 1 en
dc.identifier.startpage 10 en
dc.identifier.endpage 13 en
dc.identifier.issn 0002-0729
dc.identifier.issn 1468-2834
dc.identifier.uri http://hdl.handle.net/10468/7480
dc.identifier.doi 10.1093/ageing/afy157
dc.description.abstract Adverse drug reactions (ADRs) are a recognised unintentional form of iatrogenic harm, which commonly occur in older adults who have high levels of multi-morbidity and associated polypharmacy. Previous studies estimate that at least one in 10 hospitalised older patients will experience an ADR. While recent research indicates that this could be as high as 39% in hospitalised multi-morbid, older adults, up to two-thirds of these ADRs can be considered preventable and therefore potentially avoidable. In addition to increasing patient morbidity and contributing to avoidable mortality, there is an associated cost implication with ADR occurrence. This commentary summarises current mainstream research in terms of ADR detection, prediction and prevention in multi-morbid older patients. At present, the biggest barrier to understanding and comparing ADRs in the literature is the large heterogeneity that exists in the population and study methods. Furthermore, there is the lack of standardised universally accepted methodology for ADR prediction, detection, causality assessment and subsequent prevention in older people. Standard available methods of ADR prediction applied to a heterogeneous multi-morbid population are generally unsatisfactory. Without an instrument that consistently and reliably predicts ADR risk in a reproducible manner, ADR prevention in multi-morbid older patients is challenging. Further attention should be focused on the culprit drugs that commonly lead to major ADRs in older multi-morbid hospitalised patients with polypharmacy. Risk associated with particular drug classes may possibly predict ADR occurrence better than patient characteristics alone. Current research is examining this drug class focus for ADR prevention in multi-morbid older people. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press on behalf of the British Geriatrics Society en
dc.rights © 2018, the Authors. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Age and Ageing following peer review. The version of record is available online at: https://doi.org/10.1093/ageing/afy157 en
dc.subject Adverse drug reaction en
dc.subject Prevention en
dc.subject Prediction en
dc.subject Polypharmacy en
dc.subject Older people en
dc.title Detection and prevention of adverse drug reactions in multi-morbid older patients en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Denis O'Mahony, Medicine Department, University College Cork, Cork, Ireland. +353-21-490-3000 Email: denis.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-09-12
dc.date.updated 2019-02-12T11:38:48Z
dc.description.version Accepted Version en
dc.internal.rssid 473313232
dc.description.status Peer reviewed en
dc.identifier.journaltitle Age and Ageing en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress denis.omahony@ucc.ie en
dc.internal.IRISemailaddress emma.jennings@ucc.ie


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