Self-assembled cationic β-cyclodextrin nanostructures for siRNA delivery

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dc.contributor.author Singh, Raghvendra Pratap
dc.contributor.author Hidalgo, Tania
dc.contributor.author Cazade, Pierre-Andre
dc.contributor.author Darcy, Raphael
dc.contributor.author Cronin, Michael F.
dc.contributor.author Dorin, Irina
dc.contributor.author O'Driscoll, Caitríona M.
dc.contributor.author Thompson, Damien
dc.date.accessioned 2019-02-14T14:49:49Z
dc.date.available 2019-02-14T14:49:49Z
dc.date.issued 2019-02-05
dc.identifier.citation Singh, R. P., Hidalgo, T., Cazade, P.-A., Darcy, R., Cronin, M., Dorin, I., O'Driscoll, C. M. and Thompson, D. (2019) 'Self-assembled cationic β-cyclodextrin nanostructures for siRNA delivery', Molecular Pharmaceutics, In Press, doi: 10.1021/acs.molpharmaceut.8b01307 en
dc.identifier.startpage 1 en
dc.identifier.endpage 18 en
dc.identifier.issn 1543-8384
dc.identifier.uri http://hdl.handle.net/10468/7499
dc.identifier.doi 10.1021/acs.molpharmaceut.8b01307
dc.description.abstract Functionalised cyclodextrin molecules assemble into a wide variety of superstructures in solution, which are of interest for drug delivery and other nanomaterial and biomaterial applications. Here we use a combined simulation and experimental approach to probe the co-assembly of siRNA and cationic cyclodextrin (c-CD) derivatives into a highly stable gene delivery nanostructure. The c-CD form supramolecular structures via interdigitation of their aliphatic tails, analogous to the formation of lipid bilayers and micelles. The native conformation of siRNA is preserved by the encapsulating c-CD superstructure in an extensive hydrogen bonding network between the positively charged sidearms of c-CD and the negatively charged siRNA backbone. The stability of the complexation is confirmed using isothermal titration calorimetry, and the experimental/simulation co-design methodology opens new avenues for creation of highly-engineerable gene delivery vectors. en
dc.description.sponsorship Science Foundation Ireland (Grant Number 15/CDA/3491); Enterprise Ireland (EI innovation partnership on Advanced Biopharmaceutical Formulation) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society, ACS en
dc.relation.uri https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01307
dc.rights © American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01307 en
dc.subject siRNA en
dc.subject Gene delivery en
dc.subject Cyclodextrin en
dc.subject Self-assembly en
dc.subject Molecular dynamics en
dc.title Self-assembled cationic β-cyclodextrin nanostructures for siRNA delivery en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitriona.odriscoll@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-02-05
dc.date.updated 2019-02-14T14:37:26Z
dc.description.version Accepted Version en
dc.internal.rssid 473558312
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Regional Development Fund en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Pharmaceutics en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress caitriona.odriscoll@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Infrastructural Support/08/HEC/I1450/IE/Establishment of ICHEC as a National Facility for High-End Computing/ en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrain en


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