dc.contributor.author |
Singh, Raghvendra Pratap |
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dc.contributor.author |
Hidalgo, Tania |
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dc.contributor.author |
Cazade, Pierre-Andre |
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dc.contributor.author |
Darcy, Raphael |
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dc.contributor.author |
Cronin, Michael F. |
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dc.contributor.author |
Dorin, Irina |
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dc.contributor.author |
O'Driscoll, Caitríona M. |
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dc.contributor.author |
Thompson, Damien |
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dc.date.accessioned |
2019-02-14T14:49:49Z |
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dc.date.available |
2019-02-14T14:49:49Z |
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dc.date.issued |
2019-02-05 |
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dc.identifier.citation |
Singh, R. P., Hidalgo, T., Cazade, P.-A., Darcy, R., Cronin, M., Dorin, I., O'Driscoll, C. M. and Thompson, D. (2019) 'Self-assembled cationic β-cyclodextrin nanostructures for siRNA delivery', Molecular Pharmaceutics, In Press, doi: 10.1021/acs.molpharmaceut.8b01307 |
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dc.identifier.startpage |
1 |
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dc.identifier.endpage |
18 |
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dc.identifier.issn |
1543-8384 |
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dc.identifier.uri |
http://hdl.handle.net/10468/7499 |
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dc.identifier.doi |
10.1021/acs.molpharmaceut.8b01307 |
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dc.description.abstract |
Functionalised cyclodextrin molecules assemble into a wide variety of superstructures in solution, which are of interest for drug delivery and other nanomaterial and biomaterial applications. Here we use a combined simulation and experimental approach to probe the co-assembly of siRNA and cationic cyclodextrin (c-CD) derivatives into a highly stable gene delivery nanostructure. The c-CD form supramolecular structures via interdigitation of their aliphatic tails, analogous to the formation of lipid bilayers and micelles. The native conformation of siRNA is preserved by the encapsulating c-CD superstructure in an extensive hydrogen bonding network between the positively charged sidearms of c-CD and the negatively charged siRNA backbone. The stability of the complexation is confirmed using isothermal titration calorimetry, and the experimental/simulation co-design methodology opens new avenues for creation of highly-engineerable gene delivery vectors. |
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dc.description.sponsorship |
Science Foundation Ireland (Grant Number 15/CDA/3491); Enterprise Ireland (EI innovation partnership on Advanced Biopharmaceutical Formulation) |
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dc.format.mimetype |
application/pdf |
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dc.language.iso |
en |
en |
dc.publisher |
American Chemical Society, ACS |
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dc.relation.uri |
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01307 |
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dc.rights |
© American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01307 |
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dc.subject |
siRNA |
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dc.subject |
Gene delivery |
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dc.subject |
Cyclodextrin |
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dc.subject |
Self-assembly |
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dc.subject |
Molecular dynamics |
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dc.title |
Self-assembled cationic β-cyclodextrin nanostructures for siRNA delivery |
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dc.type |
Article (peer-reviewed) |
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dc.internal.authorcontactother |
Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitriona.odriscoll@ucc.ie |
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dc.internal.availability |
Full text available |
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dc.check.info |
Access to this article is restricted until 12 months after publication by request of the publisher. |
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dc.check.date |
2020-02-05 |
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dc.date.updated |
2019-02-14T14:37:26Z |
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dc.description.version |
Accepted Version |
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dc.internal.rssid |
473558312 |
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dc.contributor.funder |
Science Foundation Ireland
|
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dc.contributor.funder |
European Regional Development Fund
|
en |
dc.contributor.funder |
Enterprise Ireland
|
en |
dc.contributor.funder |
Horizon 2020
|
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dc.description.status |
Peer reviewed |
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dc.identifier.journaltitle |
Molecular Pharmaceutics |
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dc.internal.copyrightchecked |
No !!CORA!! |
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dc.internal.licenseacceptance |
Yes |
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dc.internal.IRISemailaddress |
caitriona.odriscoll@ucc.ie |
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dc.relation.project |
info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/
|
en |
dc.relation.project |
info:eu-repo/grantAgreement/SFI/SFI Infrastructural Support/08/HEC/I1450/IE/Establishment of ICHEC as a National Facility for High-End Computing/
|
en |
dc.relation.project |
info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrain
|
en |