Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal–infant birth cohort

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dc.contributor.author McCarthy, Elaine K.
dc.contributor.author Kenny, Louise C.
dc.contributor.author Hourihane, Jonathan O'B.
dc.contributor.author Irvine, Alan D.
dc.contributor.author Murray, Deirdre M.
dc.contributor.author Kiely, Mairead E.
dc.date.accessioned 2019-02-19T11:50:45Z
dc.date.available 2019-02-19T11:50:45Z
dc.date.issued 2016-12-21
dc.identifier.citation McCarthy, E. K., Kenny, L. C., Hourihane, J. O. B., Irvine, A. D., Murray, D. M. and Kiely, M. E. (2016) 'Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal–infant birth cohort', European Journal Of Clinical Nutrition, 71, pp. 782-787. doi: 10.1038/ejcn.2016.255 en
dc.identifier.volume 71 en
dc.identifier.startpage 782 en
dc.identifier.endpage 787 en
dc.identifier.issn 0954-3007
dc.identifier.uri http://hdl.handle.net/10468/7518
dc.identifier.doi 10.1038/ejcn.2016.255
dc.description.abstract Background/Objectives: Low serum ferritin concentrations at birth, which reflect neonatal iron stores, track through to early childhood and have been associated with poorer neurodevelopmental outcomes. We aimed to identify maternal, antenatal and birth-associated factors that influence iron stores at birth in a prospective maternal–infant birth cohort. Subjects/Methods: In a population-based, longitudinal, birth cohort in Ireland, 413 maternal–infant dyads with prospectively collected lifestyle and clinical data from 15 weeks’ gestation had umbilical cord serum ferritin concentrations measured. Regression models were developed to identify independent factors associated with cord ferritin concentrations. Results: Median (IQR) cord ferritin concentrations were 185.7 (131.7, 385.5) μg/l, and 8% (n=33) of infants had low iron stores (ferritin <76 μg/l) at birth. Maternal obesity (BMI 30 kg/m2) at 15 weeks’ gestation (adj. estimate (95% confidence interval (CI)): −66.4 (−106.9, −25.9) μg/l, P<0.0001) and delivery by caesarean section (−38.8 (−70.2, −7.4) μg/l, P=0.016) were inversely associated with cord ferritin concentrations. In addition, maternal smoking at 15 weeks’ gestation (adj. odds ratio (95% CI): 2.9 (1.2, 7), P=0.020) and being born small-for-gestational age (3.4 (1.3, 8.9), P=0.012) were associated with an increased risk of low iron stores (ferritin <76 μg/l) at birth. Conclusions: We have identified a number of potentially modifiable lifestyle factors that influence iron stores at birth, with the important role of overall maternal health and lifestyle during pregnancy highlighted. Public health policies targeting women of child-bearing age to improve nutrition and health outcomes should be prioritised for the health of the next generation. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature en
dc.relation.uri https://www.nature.com/articles/ejcn2016255
dc.rights © 2016 The Authors. This is a post-peer-review, pre-copyedit version of an article published in European Journal of Clinical Nutrition. The final authenticated version is available online at: http://dx.doi.org/10.1038/ejcn.2016.255 en
dc.subject Iron stores en
dc.subject Birth cohort en
dc.subject Neonate en
dc.subject Pregnancy en
dc.subject Caesarean section en
dc.subject Serum ferritin en
dc.title Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal–infant birth cohort en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Elaine McCarthy, Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland. +353-21-490-3000 Email: elaine.mccarthy@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-02-19T11:40:19Z
dc.description.version Accepted Version en
dc.internal.rssid 474170454
dc.contributor.funder National Children’s Research Centre, Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Journal of Clinical Nutrition en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress m.kiely@ucc.ie en
dc.internal.IRISemailaddress elaine.mccarthy@ucc.ie em


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