Planning, implementing, and running a multicentre preterm birth study with biobank resources in Brazil: The preterm SAMBA study

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dc.contributor.author Souza, Renato T.
dc.contributor.author Cecatti, Jose G.
dc.contributor.author Costa, Maria L.
dc.contributor.author Mayrink, Jussara
dc.contributor.author Pacagnella, Rodolfo C.
dc.contributor.author Passini Jr, Renato
dc.contributor.author Franchini, Kleber G.
dc.contributor.author Feitosa, Francisco E.
dc.contributor.author Calderon, Iracema M.
dc.contributor.author Rocha Filho, Edilberto A.
dc.contributor.author Leite, Débora F.
dc.contributor.author Vettorazzi, Janete
dc.contributor.author Kenny, Louise C.
dc.contributor.author Baker, Philip N.
dc.contributor.author The Preterm SAMBA Study Group
dc.date.accessioned 2019-03-11T12:37:50Z
dc.date.available 2019-03-11T12:37:50Z
dc.date.issued 2018
dc.identifier.citation Souza, R.T., Cecatti, J.G., Costa, M.L., Mayrink, J., Pacagnella, R.C., Passini, R., Franchini, K.G., Feitosa, F.E., Calderon, I.M., Rocha Filho, E.A. and Leite, D.F., 2019. Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm SAMBA Study. BioMed Research International, 2019, 5476350 (8pp.) DOI:10.1155/2019/5476350 en
dc.identifier.volume 2019 en
dc.identifier.startpage 1 en
dc.identifier.endpage 8 en
dc.identifier.issn 2314-6133
dc.identifier.uri http://hdl.handle.net/10468/7599
dc.identifier.doi 10.1155/2019/5476350
dc.description.abstract Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Methods. We described phases of planning, implementing, and running the Preterm SAMBA study, a multicentre Brazilian cohort study of low-risk nulliparous pregnant women, to validate a set of metabolite biomarkers for preterm birth identified in an external cohort. Procedures and strategies used to plan, implement, and maintain this multicentre preterm birth study are described in detail. Barriers and experience cited in the current narrative are not usually discussed in the scientific literature or published study protocols. Results. Several barriers and strategies were identified in different phases of the Preterm SAMBA study at different levels of the study framework (steering committee; coordinating and local centres). Strategies implemented and resources used in the study are a legacy of the Brazilian Network, aimed at training collaborators in such complex settings. Conclusion. The Brazilian Network for Studies on Reproductive and Perinatal Health has gained some experience in conducting a multicentre cohort study using a resourceful biobank which may be helpful to other research groups and maternal/perinatal health networks that plan on employing a similar approach to a similar background. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Hindawi en
dc.relation.uri https://www.hindawi.com/journals/bmri/2019/5476350/abs/
dc.rights © 2019 Renato T. Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Preterm birth study en
dc.subject Public health en
dc.subject Antenatal care en
dc.title Planning, implementing, and running a multicentre preterm birth study with biobank resources in Brazil: The preterm SAMBA study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Prof Louise Kenny, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BioMed Research International en
dc.internal.IRISemailaddress l.kenny@ucc.ie
dc.identifier.articleid 5476350


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© 2019 Renato T. Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2019 Renato T. Souza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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