Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection

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Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection

Vazquez, Patricia; Herzog, Grégoire; O'Mahony, Conor; O'Brien, Joseph; Scully, James; Blake, Alan; Ó Mathúna, S. Cian; Galvin, Paul
Date: 2014-05-02
Copyright: © 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Copyright information: http://creativecommons.org/licenses/by-nc-nd/4.0/
Related: http://www.sciencedirect.com/science/article/pii/S0925400514004912
Citation: Vazquez, P., Herzog, G., O’Mahony, C., O’Brien, J., Scully, J., Blake, A., O’Mathuna, C. and Galvin, P. (2014) 'Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection', Sensors and Actuators B: Chemical, 201, pp. 572-578. doi: 10.1016/j.snb.2014.04.080
Published Version: 10.1016/j.snb.2014.04.080

Abstract:

This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.

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© 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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