Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection

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Date
2014-05-02
Authors
Vazquez, Patricia
Herzog, Grégoire
O'Mahony, Conor
O'Brien, Joseph
Scully, James
Blake, Alan
Ó Mathúna, S. Cian
Galvin, Paul
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Elsevier
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Abstract
This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.
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Keywords
Microneedles , Micro-interfaces , ITIES , Minimally invasive , Stripping voltammetry , β-Blocker drug
Citation
Vazquez, P., Herzog, G., O’Mahony, C., O’Brien, J., Scully, J., Blake, A., O’Mathuna, C. and Galvin, P. (2014) 'Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection', Sensors and Actuators B: Chemical, 201, pp. 572-578. doi: 10.1016/j.snb.2014.04.080