Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection

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dc.contributor.author Vazquez, Patricia
dc.contributor.author Herzog, Grégoire
dc.contributor.author O'Mahony, Conor
dc.contributor.author O'Brien, Joseph
dc.contributor.author Scully, James
dc.contributor.author Blake, Alan
dc.contributor.author Ó Mathúna, S. Cian
dc.contributor.author Galvin, Paul
dc.date.accessioned 2019-05-22T14:56:48Z
dc.date.available 2019-05-22T14:56:48Z
dc.date.issued 2014-05-02
dc.identifier.citation Vazquez, P., Herzog, G., O’Mahony, C., O’Brien, J., Scully, J., Blake, A., O’Mathuna, C. and Galvin, P. (2014) 'Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection', Sensors and Actuators B: Chemical, 201, pp. 572-578. doi: 10.1016/j.snb.2014.04.080 en
dc.identifier.volume 201 en
dc.identifier.startpage 572 en
dc.identifier.endpage 578 en
dc.identifier.issn 0925-4005
dc.identifier.uri http://hdl.handle.net/10468/7969
dc.identifier.doi 10.1016/j.snb.2014.04.080 en
dc.description.abstract This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0925400514004912
dc.rights © 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Microneedles en
dc.subject Micro-interfaces en
dc.subject ITIES en
dc.subject Minimally invasive en
dc.subject Stripping voltammetry en
dc.subject β-Blocker drug en
dc.title Microscopic gel – liquid interfaces supported by hollow microneedle array for voltammetric drug detection en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Cian O Mathuna, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: cian.omathuna@tyndall.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-05-22T14:46:23Z
dc.description.version Accepted Version en
dc.internal.rssid 486169033
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Sensors and Actuators B: Chemical en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress cian.omathuna@tyndall.ie en
dc.internal.IRISemailaddress conor.omahony@tyndall.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/I1147/IE/CSET CLARITY: Bringing Information to Life/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/10/CE/B1821/IE/CSET BDI: Biomedical Diagnostics Institute/ en


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© 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2014 Elsevier B. V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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