Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses

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dc.contributor.author Gururajan, Anand
dc.contributor.author van de Wouw, Marcel
dc.contributor.author Boehme, Marcus
dc.contributor.author Becker, Thorsten
dc.contributor.author O'Connor, Rory
dc.contributor.author Bastiaanssen, Thomaz F. S.
dc.contributor.author Moloney, Gerard M.
dc.contributor.author Lyte, Joshua M.
dc.contributor.author Ventura Silva, Ana Paula
dc.contributor.author Merckx, Barbara
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2019-06-07T09:23:11Z
dc.date.available 2019-06-07T09:23:11Z
dc.date.issued 2019-05-03
dc.identifier.citation Gururajan, A., van de Wouw, M., Boehme, M., Becker, T., O'Connor, R., Bastiaanssen, T. F. S., Moloney, G. M., Lyte, J. M., Ventura Silva, A. P., Merckx, B., Dinan, T. G. and Cryan, J. F. (2019) 'Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses', Brain, Behavior, and Immunity. doi: 10.1016/j.bbi.2019.05.004 en
dc.identifier.issn 0889-1591
dc.identifier.uri http://hdl.handle.net/10468/8032
dc.identifier.doi 10.1016/j.bbi.2019.05.004 en
dc.description.abstract Research into the molecular basis of stress resilience is a novel strategy to identify potential therapeutic strategies to treat stress-induced psychopathologies such as anxiety and depression. Stress resilience is a phenomenon which is not solely driven by effects within the central nervous system (CNS) but involves multiple systems, central and peripheral, which interact with and influence each other. Accordingly, we used the chronic social defeat stress paradigm and investigated specific CNS, endocrine and immune responses to identify signatures of stress-resilience and stress susceptibility in mice. Our results showed that mice behaviourally susceptible to stress (indexed by a reduction in social interaction behaviour) had higher plasma corticosterone levels and adrenal hypertrophy. An increase in inflammatory circulating monocytes was another hallmark of stress susceptibility. Furthermore, prefrontal cortex mRNA expression of corticotrophin-releasing factor (Crf) was increased in susceptible mice relative to resilient mice. We also report differences in hippocampal synaptic plasticity between resilient and susceptible mice. Ongoing studies will interpret the functional relevance of these signatures which could potentially inform the development of novel psychotherapeutic strategies. en
dc.description.sponsorship Science Foundation Ireland (15/JP‐HDHL/3270; JPI‐HDHL‐NutriCog project ‘AMBROSIAC) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Inc. en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S088915911830727X
dc.rights © 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Stress resilience en
dc.subject Neuroendocrine en
dc.subject Corticotrophin-releasing factor en
dc.subject Prefrontal cortex en
dc.subject Synaptic plasticity en
dc.subject Inflammatory monocytes en
dc.title Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-05-03
dc.date.updated 2019-06-07T09:07:59Z
dc.description.version Accepted Version en
dc.internal.rssid 488127297
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Brain, Behavior, and Immunity en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/704995/EU/Decoding Stress Resilience/DE-STRESS en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1090-2139


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© 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.
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