The impact of recent developments in technologies which enable the increased use of biocatalysts

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The impact of recent developments in technologies which enable the increased use of biocatalysts

Foley, Aoife M.; Maguire, Anita R.
Date: 2019-04-10
Copyright: © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Foley, A. M. and Maguire, A. R. (2019), The Impact of Recent Developments in Technologies which Enable the Increased Use of Biocatalysts. Eur. J. Org. Chem., 2019: 3713-3734, which has been published in final form at https://doi.org/10.1002/ejoc.201900208. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Related: https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201900208
Full text restriction information: Access to this article is restricted until 12 months after publication by request of the publisher.
Restriction lift date: 2020-04-10
Citation: Foley, A. M. and Maguire, A. R. (2019) 'The Impact of Recent Developments in Technologies which Enable the Increased Use of Biocatalysts', European Journal of Organic Chemistry, (23), pp. 3713-3734. doi: 10.1002/ejoc.201900208
Published Version: 10.1002/ejoc.201900208

Abstract:

While biocatalytic transformations are very powerful in enantioselective synthesis, frequently occurring under mild conditions, and proceed with extraordinary selectivity, there are practical challenges associated with the use of biocatalysis, such as limited substrate scope, stability, and reusability. Recent technological developments, for example immobilization, continuous flow, and molecular biology, all contribute towards enhancing the use of enzymes in synthesis.

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