Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition

Show simple item record

dc.contributor.author Codagnone, Martin G.
dc.contributor.author Stanton, Catherine
dc.contributor.author O'Mahony, Siobhain M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2019-07-22T09:53:37Z
dc.date.available 2019-07-22T09:53:37Z
dc.date.issued 2019-06-24
dc.identifier.citation Codagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144 en
dc.identifier.volume 74 en
dc.identifier.issued Supplement 2 en
dc.identifier.startpage 16 en
dc.identifier.endpage 27 en
dc.identifier.issn 0250-6807
dc.identifier.uri http://hdl.handle.net/10468/8211
dc.identifier.doi 10.1159/000499144 en
dc.description.abstract Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Karger Publishers en
dc.relation.uri https://www.karger.com/DOI/10.1159/000499144
dc.rights © 2019, S. Karger AG, Basel. This is the peer-reviewed but unedited manuscript version of the following article: Codagnone, M. G., Stanton, C., O'Mahony, S. M., Dinan, T. G. and Cryan, J. F. (2019) 'Microbiota and neurodevelopmental trajectories: Role of maternal and early-life nutrition', Annals of Nutrition and Metabolism, 74(Supplement 2), pp. 16-27. doi: 10.1159/000499144. The final, published version is available at https://www.karger.com/?doi=10.1159/000499144 en
dc.subject Microbiota en
dc.subject Neuropsychiatry en
dc.subject Gut-brain axis en
dc.subject Brain development en
dc.subject Early life en
dc.subject Stress en
dc.subject Diet en
dc.subject Nutrition en
dc.title Microbiota and neurodevelopmental trajectories: role of maternal and early-life nutrition en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-07-22T09:31:17Z
dc.description.version Accepted Version en
dc.internal.rssid 493777472
dc.contributor.funder Nestlé Nutrition Institute en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Annals of Nutrition and Metabolism en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEX en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1421-9697


Files in this item

This item appears in the following Collection(s)

Show simple item record

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement