Microbiome and skin biology

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dc.contributor.author Lunjani, Nonhlanhla
dc.contributor.author Hlela, Carol
dc.contributor.author O'Mahony, Liam
dc.date.accessioned 2019-08-07T11:51:34Z
dc.date.available 2019-08-07T11:51:34Z
dc.date.issued 2019-08-01
dc.identifier.citation Lunjani, N., Hlela, C. and O'Mahony, L. (2019) 'Microbiome and skin biology', Current Opinion in Allergy and Clinical Immunology, 19(4), pp. 328-333. doi: 10.1097/aci.0000000000000542 en
dc.identifier.volume 19 en
dc.identifier.issued 4 en
dc.identifier.startpage 328 en
dc.identifier.endpage 333 en
dc.identifier.issn 1528-4050
dc.identifier.uri http://hdl.handle.net/10468/8293
dc.identifier.doi 10.1097/aci.0000000000000542 en
dc.description.abstract Purpose of review: The skin is home to a diverse milieu of bacteria, fungi, viruses, bacteriophages, and archaeal communities. The application of culture-independent approaches has revolutionized the characterization of the skin microbiome and have revealed a previously underappreciated phylogenetic and functional granularity of skin-associated microbes in both health and disease states. Recent findings: The physiology of a given skin-niche drives the site-specific differences in bacterial phyla composition of healthy skin. Changes in the skin microbiome have consistently been associated with atopic dermatitis. In particular, Staphylococcus aureus overgrowth with concomitant decline in Staphylococcus epidermidis is a general feature associated with atopic dermatitis and is not restricted to eczematous lesions. Changes in fungal species are now also being described. Changes in the composition and metabolic activity of the gut microbiota are associated with skin health. Summary: We are now beginning to appreciate the intimate and intricate interactions between microbes and skin health. Multiple studies are currently focused on the manipulation of the skin or gut microbiome to explore their therapeutic potential in the prevention and treatment of skin inflammation. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.uri https://journals.lww.com/co-allergy/Fulltext/2019/08000/Microbiome_and_skin_biology.10.aspx
dc.rights © 2019, Wolters Kluwer Health, Inc. All rights reserved. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Current Opinion in Allergy and Clinical Immunology. To access the final edited and published work see: https://doi.org/10.1097/aci.0000000000000542 en
dc.subject Atopic dermatitis en
dc.subject Malassezia en
dc.subject Microbiome en
dc.subject Staphylococcus aureus en
dc.title Microbiome and skin biology en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Liam O'Mahony, Medicine Department, University College Cork, Cork, Ireland. +353-21-490-3000 Email: liam.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-08-01
dc.date.updated 2019-08-07T11:41:42Z
dc.description.version Accepted Version en
dc.internal.rssid 495735315
dc.description.status Peer reviewed en
dc.identifier.journaltitle Current Opinion in Allergy and Clinical Immunology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress liam.omahony@ucc.ie en
dc.identifier.eissn 1473-6322

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