Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

Show simple item record Manzari, Nicla Matvienko-Sikar, Karen Baldoni, Franco O'Keeffe, Gerard W. Khashan, Ali S. 2019-08-08T09:02:04Z 2019-08-08T09:02:04Z 2019-07-20
dc.identifier.citation Manzari, N., Matvienko-Sikar, K., Baldoni, F., O'Keeffe, G. W. and Khashan, A. S. (2019) 'Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis', Social Psychiatry and Psychiatric Epidemiology. doi: 10.1007/s00127-019-01745-3 en
dc.identifier.startpage 1 en
dc.identifier.endpage 11 en
dc.identifier.issn 0933-7954
dc.identifier.doi 10.1007/s00127-019-01745-3 en
dc.description.abstract Purpose: Exposure to prenatal stress has been reported to affect the risk of adverse neurodevelopmental outcomes in the offspring; however, there is currently no clear consensus. The aim of this systematic review and meta-analysis was to examine the existing literature on the association between prenatal stress and autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in the offspring. Methods: Based on a registered protocol, we searched several electronic databases for articles in accordance with a detailed search strategy. We performed this study following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Results: Prenatal stress was significantly associated with an increased risk of both ASD (pooled OR 1.64 [95% CI 1.15–2.34]; I2 = 90%; 15 articles) and ADHD (pooled OR 1.72 [95% CI 1.27–2.34]; I2 = 85%; 12 articles). Conclusions: This study suggests that prenatal stress may be associated with ASD and ADHD; however, several limitations in the reviewed literature should be noted including significant heterogeneity and there is a need for carefully controlled future studies in this area. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Switzerland AG en
dc.rights © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Social Psychiatry and Psychiatric Epidemiology. The final authenticated version is available online at: en
dc.subject Autism spectrum disorder en
dc.subject Attention-deficit/hyperactivity disorder Prenatal maternal stress en
dc.subject Pregnancy en
dc.subject Mental health en
dc.title Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard O'Keeffe, Anatomy and Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication by request of the publisher. en 2020-07-20 2019-08-08T08:44:06Z
dc.description.version Accepted Version en
dc.internal.rssid 495735232
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Social Psychiatry and Psychiatric Epidemiology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en
dc.internal.IRISemailaddress en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.identifier.eissn 1433-9285

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