Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

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dc.contributor.author Manzari, Nicla
dc.contributor.author Matvienko-Sikar, Karen
dc.contributor.author Baldoni, Franco
dc.contributor.author O'Keeffe, Gerard W.
dc.contributor.author Khashan, Ali S.
dc.date.accessioned 2019-08-08T09:02:04Z
dc.date.available 2019-08-08T09:02:04Z
dc.date.issued 2019-07-20
dc.identifier.citation Manzari, N., Matvienko-Sikar, K., Baldoni, F., O'Keeffe, G. W. and Khashan, A. S. (2019) 'Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis', Social Psychiatry and Psychiatric Epidemiology. doi: 10.1007/s00127-019-01745-3 en
dc.identifier.startpage 1 en
dc.identifier.endpage 11 en
dc.identifier.issn 0933-7954
dc.identifier.uri http://hdl.handle.net/10468/8296
dc.identifier.doi 10.1007/s00127-019-01745-3 en
dc.description.abstract Purpose: Exposure to prenatal stress has been reported to affect the risk of adverse neurodevelopmental outcomes in the offspring; however, there is currently no clear consensus. The aim of this systematic review and meta-analysis was to examine the existing literature on the association between prenatal stress and autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in the offspring. Methods: Based on a registered protocol, we searched several electronic databases for articles in accordance with a detailed search strategy. We performed this study following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Results: Prenatal stress was significantly associated with an increased risk of both ASD (pooled OR 1.64 [95% CI 1.15–2.34]; I2 = 90%; 15 articles) and ADHD (pooled OR 1.72 [95% CI 1.27–2.34]; I2 = 85%; 12 articles). Conclusions: This study suggests that prenatal stress may be associated with ASD and ADHD; however, several limitations in the reviewed literature should be noted including significant heterogeneity and there is a need for carefully controlled future studies in this area. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Switzerland AG en
dc.rights © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Social Psychiatry and Psychiatric Epidemiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00127-019-01745-3 en
dc.subject Autism spectrum disorder en
dc.subject Attention-deficit/hyperactivity disorder Prenatal maternal stress en
dc.subject Pregnancy en
dc.subject Mental health en
dc.title Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard O'Keeffe, Anatomy and Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.okeeffe@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-07-20
dc.date.updated 2019-08-08T08:44:06Z
dc.description.version Accepted Version en
dc.internal.rssid 495735232
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Social Psychiatry and Psychiatric Epidemiology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.okeeffe@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.identifier.eissn 1433-9285


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