IL-1 family members in cancer; two sides to every story

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dc.contributor.author Baker, Kevin J.
dc.contributor.author Houston, Aileen M.
dc.contributor.author Brint, Elizabeth K.
dc.date.accessioned 2019-09-04T15:44:14Z
dc.date.available 2019-09-04T15:44:14Z
dc.date.issued 2019-06-07
dc.identifier.citation Baker, K. J., Houston, A. and Brint, E. (2019) 'IL-1 Family Members in Cancer; Two Sides to Every Story', Frontiers in Immunology, 10, 1197 (16 pp). doi: 10.3389/fimmu.2019.01197 en
dc.identifier.volume 10 en
dc.identifier.startpage 1 en
dc.identifier.endpage 16 en
dc.identifier.issn 1664-3224
dc.identifier.uri http://hdl.handle.net/10468/8454
dc.identifier.doi 10.3389/fimmu.2019.01197 en
dc.description.abstract The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer. en
dc.description.sponsorship Irish Research Council (Government of Ireland grant (GOIPG/2018/2974)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2019 Baker, Houston and Brint. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Interleukin-1 (IL-1) en
dc.subject Inflammation en
dc.subject Cancer en
dc.subject IL-18 en
dc.subject IL-33 en
dc.subject IL-36 family interleukins en
dc.subject Predicts poor prognosis en
dc.subject Inhibits tumor growth en
dc.subject Natural killer cells en
dc.subject Pancreatic cancer en
dc.subject Ovarian cancer en
dc.subject T-cells en
dc.subject Serum interleukin-18 en
dc.subject Metastatic phenotype en
dc.subject Acquired immunity en
dc.title IL-1 family members in cancer; two sides to every story en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Aileen Houston, Medicine Department , University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.houston@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-09-02T06:12:19Z
dc.description.version Published Version en
dc.internal.rssid 490085880
dc.internal.wokid WOS:000470990500001
dc.contributor.funder Irish Research Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers In Immunology en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.houston@ucc.ie en
dc.identifier.articleid 1197 en


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© 2019 Baker, Houston and Brint. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2019 Baker, Houston and Brint. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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