The gut microbiome and atherosclerosis: current knowledge and clinical potential

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dc.contributor.author Ahmad, Adilah
dc.contributor.author Dwivedi, Girish
dc.contributor.author O'Gara, Fergal
dc.contributor.author Caparros-Martin, Jose
dc.contributor.author Ward, Natalie
dc.date.accessioned 2019-09-06T11:49:01Z
dc.date.available 2019-09-06T11:49:01Z
dc.date.issued 2019-08-30
dc.identifier.citation Ahmad, A., Dwivedi, G., O'Gara, F., Caparros-Martin, J. and Ward, N. (2019) 'The gut microbiome and atherosclerosis: current knowledge and clinical potential', American Journal of Physiology - Heart and Circulatory Physiology. doi: 10.1152/ajpheart.00376.2019 en
dc.identifier.issn 0363-6135
dc.identifier.uri http://hdl.handle.net/10468/8462
dc.identifier.doi 10.1152/ajpheart.00376.2019 en
dc.description.abstract Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body is populated by a diverse community of microbes, dominated by bacteria, but also including viruses and fungi. The largest and most complex of these communities is located in the gastrointestinal system and with their associated genome, are known as the gut microbiome. Gut microbiome perturbations and related dysbiosis have been implicated in the progression and pathogenesis of CVD, including atherosclerosis, hypertension and heart failure. Although there have been advances in the characterisation and analysis of the gut microbiota and associated bacterial metabolites, the exact mechanisms through which they exert their action is not well understood. This review will focus on the role of the gut microbiome and associated functional components in the development and progression of atherosclerosis. Potential treatments to alter the gut microbiome to prevent or treat atherosclerosis and CVD are also discussed. en
dc.description.sponsorship Department of Education, Employment and Workplace Relations, Australian Government (Research Training Program (RTP) Scholarship); University of Western Australia (Wesfarmers Chair in Cardiology) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Physiological Society en
dc.relation.uri https://www.physiology.org/doi/abs/10.1152/ajpheart.00376.2019
dc.rights © 2019, American Journal of Physiology-Heart and Circulatory Physiology. All rights reserved. en
dc.subject Atherosclerosis en
dc.subject Cardiovascular disease en
dc.subject Dysbiosis en
dc.subject Microbiome en
dc.subject TMAO en
dc.title The gut microbiome and atherosclerosis: current knowledge and clinical potential en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergal O'Gara, Microbiology , University College Cork, Cork, Ireland. +353-21-490-3000 Email: f.ogara@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-08-30
dc.date.updated 2019-09-06T11:37:52Z
dc.description.version Accepted Version en
dc.internal.rssid 499406462
dc.contributor.funder Department of Education, Employment and Workplace Relations, Australian Government en
dc.contributor.funder University of Western Australia en
dc.description.status Peer reviewed en
dc.identifier.journaltitle American Journal of Physiology - Heart and Circulatory Physiology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress f.ogara@ucc.ie en
dc.internal.bibliocheck In press. Check vol / issue / page range. Amend citation as necessary. en
dc.identifier.eissn 1522-1539


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