The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

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dc.contributor.author O'Mahony, Siobhain M.
dc.contributor.author McVey Neufeld, Karen-Anne
dc.contributor.author Waworuntu, Rosaline V.
dc.contributor.author Pusceddu, Matteo M.
dc.contributor.author Manurung, Sarmauli
dc.contributor.author Murphy, Kiera
dc.contributor.author Strain, Conall
dc.contributor.author Laguna, Mamen C.
dc.contributor.author Peterson, Veronica L.
dc.contributor.author Stanton, Catherine
dc.contributor.author Berg, Brian M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2019-09-09T11:29:23Z
dc.date.available 2019-09-09T11:29:23Z
dc.date.issued 2019-07-24
dc.identifier.citation O'Mahony, S. M., McVey Neufeld, K.-A., Waworuntu, R. V., Pusceddu, M. M., Manurung, S., Murphy, K., Strain, C., Laguna, M. C., Peterson, V. L., Stanton, C., Berg, B. M., Dinan, T. G. and Cryan, J. F. (2019) 'The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend', European Journal of Neurology, 2019, pp. 1-17. doi: 10.1111/ejn.14514 en
dc.identifier.volume 2019 en
dc.identifier.startpage 1 en
dc.identifier.endpage 17 en
dc.identifier.issn 0953-816X
dc.identifier.uri http://hdl.handle.net/10468/8474
dc.identifier.doi 10.1111/ejn.14514 en
dc.description.abstract Nutritional interventions targeting the microbiota-gut-brain axis are proposed to modulate stress-induced dysfunction of physiological processes and brain development. Maternal separation (MS) in rats induces long-term alterations to behavior, pain responses, gut microbiome and brain neurochemistry. In this study, the effects of dietary interventions (milk fat globule membrane (MFGM) and a polydextrose/galactooligosaccharide prebiotic blend (PDX/GOS)) were evaluated. Diets were provided from postnatal day 21 to both non-separated (NS) and MS offspring. Spatial memory, visceral sensitivity and stress reactivity were assessed in adulthood. Gene transcripts associated with cognition and stress and the caecal microbiota composition were analysed. MS-induced visceral hypersensitivity was ameliorated by MFGM and to greater extent with the combination of MFGM and prebiotic blend. Furthermore, spatial learning and memory were improved by prebiotics and MFGM alone and with the combination. The prebiotic blend and the combination of the prebiotics and MFGM appeared to facilitate return to baseline with regard to HPA axis response to the restraint stress which can be beneficial in times where coping mechanisms to stressful events are required. Interestingly, the combination of MFGM and prebiotic reduced the long-term impact of MS on a marker of myelination in the prefrontal cortex. MS affected the microbiota at family level only while MFGM, the prebiotic blend and the combination influenced abundance at family and genus level as well as influencing beta diversity levels. In conclusion, intervention with MFGM and prebiotic blend significantly impacted the composition of the microbiota as well as ameliorating some of the long-term effects of early-life stress. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14514
dc.rights © 2019, Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is the peer reviewed version of the following article: O'Mahony, S. M., McVey Neufeld, K.-A., Waworuntu, R. V., Pusceddu, M. M., Manurung, S., Murphy, K., Strain, C., Laguna, M. C., Peterson, V. L., Stanton, C., Berg, B. M., Dinan, T. G. and Cryan, J. F. (2019) 'The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend', European Journal of Neurology, 2019, pp. 1-17. doi: 10.1111/ejn.14514, which has been published in final form at https://doi.org/10.1111/ejn.14514. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Maternal separation en
dc.subject Postnatal en
dc.subject Neurodevelopment en
dc.subject Visceral hypersensitivity en
dc.title The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Siobhain O'Mahony, Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: somahony@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-07-24
dc.date.updated 2019-08-01T09:15:30Z
dc.description.version Accepted Version en
dc.internal.rssid 495000859
dc.contributor.funder Mead Johnson Nutrition en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Journal of Neurology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress somahony@ucc.ie en
dc.internal.bibliocheck Early View: Check vol / issue / page range. Amend citation as necessary.


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