Characterisation of a hydroxycinnamic acid esterase from the Bifidobacterium longum subsp. longum taxon

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Show simple item record Kelly, Sandra M. O'Callaghan, John Kinsella, Mike van Sinderen, Douwe 2019-09-09T11:51:21Z 2019-09-09T11:51:21Z 2018-11-09
dc.identifier.citation Kelly, S.M., O’Callaghan, J., Kinsella, M. and Van Sinderen, D., 2018. Characterisation of a hydroxycinnamic acid esterase from the Bifidobacterium longum subsp. longum taxon. Frontiers in Microbiology, 9 (2690). DOI:10.3389/fmicb.2018.02690 en
dc.identifier.volume 9 en
dc.identifier.startpage 1 en
dc.identifier.endpage 14 en
dc.identifier.doi 10.3389/fmicb.2018.02690 en
dc.description.abstract Bifidobacterium longum subsp. longum, a common member of the human gut microbiota with perceived positive health effects, is capable of metabolising certain complex plant carbohydrates which are typically found in the (adult) human diet. Potentially, these plant carbohydrates possibly could be employed to favourably modulate the microbial communities in the intestine. Hydroxycinnamic acids (HCAs) are plant phenolic compounds, attached to plant carbohydrates, which are associated with anti-oxidant and other beneficial properties. However, very little information is available regarding possible metabolism of HCA-containing glycans by bifidobacteria. In the current study, a gene encoding a hydroxycinnamic acid esterase was found to be conserved across the B. longum subsp. longum taxon and was present in a conserved locus associated with plant carbohydrate utilisation. The esterase was shown to be active against various HCA-containing substrates and was biochemically characterised in terms of substrate preference, and pH and temperature optima of the enzyme. Potentially, this novel hydroxycinnamic acid esterase could release HCAs from plant-based dietary sources, which may have benefits for the gut environment and thus host health. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2018 Kelly, O’Callaghan, Kinsella and van Sinderen en
dc.rights.uri en
dc.subject Esterase en
dc.subject Hydroxycinnamic acid en
dc.subject Ferulic acid en
dc.subject Bifidoacterium longum en
dc.subject Plant phenolics en
dc.subject P- coumaric acid en
dc.subject Caffeic acid en
dc.title Characterisation of a hydroxycinnamic acid esterase from the Bifidobacterium longum subsp. longum taxon en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Douwe van Sinderen, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress en
dc.identifier.articleid 2690 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/13/IA/1953/IE/Functional analysis of the host adsorption and DNA injection processes of a lactococcal bacteriophage/ en
dc.identifier.eissn 1664-302X

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© 2018 Kelly, O’Callaghan, Kinsella and van Sinderen Except where otherwise noted, this item's license is described as © 2018 Kelly, O’Callaghan, Kinsella and van Sinderen
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