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Encapsulated cyclosporine does not change the composition of the human microbiota when assessed ex vivo and in vivo

O'Reilly, Catherine; O'Sullivan, Orla; Cotter, Paul D.; O'Connor, Paula M.; Shanahan, Fergus; Cullen, Alan; Rea, Mary C.; Hill, Colin; Coulter, Ivan; Ross, R. Paul (Microbiology Society, 2020-01)

Introduction: Management of steroid-refractory ulcerative colitis has predominantly involved treatment with systemic cyclosporine A (CyA) and infliximab. Aim. The purpose of this study was to assess the effect of using a ...
Probiotics and non-alcoholic fatty liver disease in children and adolescents: a systematic review

Avelar-Rodríguez, David; Peña-Vélez, Rubén; Popov, Jelena; Hill, Lee; MacDaragh Ryan, Paul (Sociedad Española de Patología Digestiva (SEPD), 2022-11-22)

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) in childhood is an increasing public health issue globally with significant long-term consequences. NAFLD management mainly consists of lifestyle modifications, however, ...
The separate effects of whole oats and isolated beta-glucan on lipid profile: a systematic review and meta-analysis of randomized controlled trials

de Morais Junior, Alcides C.; Schincaglia, Raquel M.; Viana, Ricardo B.; Armet, Anissa M.; Prado, Carla M.; Walter, Jens; Mota, João F. (Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism, 2022-12-19)

Background & Aims: It is well known that dietary fiber positively impacts the microbiome and health as a whole. However, the health effects of β-glucan, a dietary fiber extracted from oats, have been questioned when ...
A new approach to dose reference levels in pediatric CT: Age and size-specific dose estimation

Rawashdeh, Mohammad; Saade, Charbel; Al Mousa, Dana S.; Abdelrahman, Mostafa; Kumar, Praveen; McEntee, Mark (Elsevier Ltd., 2022-12-20)

Background: Although paediatrics' are more radio-sensitivity than adults, the number of requested paediatric CT examinations is increasing globally. Significant efforts have been focused on achieving the lowest possible ...
A randomized phase 2 study of neoadjuvant carboplatin and paclitaxel with or without atezolizumab in triple negative breast cancer (TNBC) - NCI 10013

Ademuyiwa, Foluso O.; Gao, Feng; Street, Cherease R.; Chen, Ina; Northfelt, Donald W.; Wesolowski, Robert; Arora, Mili; Brufsky, Adam; Dees, E. Claire; Santa-Maria, Cesar A.; Connolly, Roisin M.; Force, Jeremy; Moreno-Aspitia, Alvaro; Herndon, John M.; Carmody, Madelyn; Davies, Sherri R.; Larson, Sarah; Pfaff, Kathleen L.; Jones, Stephanie M.; Weirather, Jason L.; Giobbie-Hurder, Anita; Rodig, Scott J.; Liu, Zheng; Hagemann, Ian S.; Sharon, Elad; Gillanders, William E. (Springer Nature Limited, 2022-12-30)

Atezolizumab with chemotherapy has shown improved progression-free and overall survival in patients with metastatic PD-L1 positive triple negative breast cancer (TNBC). Atezolizumab with anthracycline- and taxane-based ...

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