The success of microneedle-mediated vaccine delivery into skin
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Date
2016-11-01
Authors
Marshall, Sarah
Sahm, Laura J.
Moore, Anne C.
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Group
Published Version
Abstract
Microneedles (MNs) are designed to specifically target the outermost, skin barrier layer, the stratum corneum, creating transient pathways for minimally invasive transcutaneous delivery. It is reported that MNs can facilitate delivery without stimulating the pain receptors or damaging blood vessels that lie beneath, thus being perceived as painless and associated with reduced bleeding. This immunocompetence of the skin, coupled with its ease of access, makes this organ an attractive vaccination site. The purpose of this review was to collate primary scientific literature pertaining to MN-mediated in vivo vaccination programmes. A total of 62 original research articles are presented, compiling vaccination strategies in 6 different models (mouse, rat, guinea pig, rabbit, pig, macaque and human). Vaccines tested span a wide range of viral, bacterial and protozoan pathogens and includes 7 of the 13 vaccine-preventable diseases, as defined by the WHO. This review highlights the paucity of available clinical trial data. MN-delivered vaccines have demonstrated safety and immunogenicity in pre-clinical models and boast desirable attributes such as painless administration, thermostability, dose-sparing capacity and the potential for self-administration. These advantages should contribute to enhanced global vaccine access.
Description
Keywords
Microneedle , Skin , Vaccine
Citation
Marshall, S., Sahm, L. J. and Moore, A. C. (2016) 'The success of microneedle-mediated vaccine delivery into skin', Human Vaccines and Immunotherapeutics, 12(11), pp. 2975-2983. doi: 10.1080/21645515.2016.1171440
Link to publisher’s version
Copyright
© 2016, Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in Human Vaccines and Immunotherapeutics on 1 November 2016, available online: https://doi.org/10.1080/21645515.2016.1171440