Within-host interference competition can prevent invasion of rare parasites

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dc.contributor.author Quigley, Benjamin J. Z.
dc.contributor.author Brown, Sam P.
dc.contributor.author Leggett, Helen C.
dc.contributor.author Scanlan, Pauline D.
dc.contributor.author Buckling, Angus
dc.date.accessioned 2019-09-19T09:28:01Z
dc.date.available 2019-09-19T09:28:01Z
dc.date.issued 2017-05-15
dc.identifier.citation Quigley, B. J. Z., Brown, S. P., Leggett, H. C., Scanlan, P. D. and Buckling, A. (2017) 'Within-host interference competition can prevent invasion of rare parasites', Journal of Parasitology, 145(6), pp. 770-774. doi: 10.1017/S003118201700052X en
dc.identifier.volume 145 en
dc.identifier.issued 6 en
dc.identifier.startpage 770 en
dc.identifier.endpage 774 en
dc.identifier.issn 0022-3395
dc.identifier.uri http://hdl.handle.net/10468/8569
dc.identifier.doi 10.1017/S003118201700052X en
dc.description.abstract Competition between parasite species or genotypes can play an important role in the establishment of parasites in new host populations. Here, we investigate a mechanism by which a rare parasite is unable to establish itself in a host population if a common resident parasite is already present (a 'priority effect'). We develop a simple epidemiological model and show that a rare parasite genotype is unable to invade if coinfecting parasite genotypes inhibit each other's transmission more than expected from simple resource partitioning. This is because a rare parasite is more likely to be in multiply-infected hosts than the common genotype, and hence more likely to pay the cost of reduced transmission. Experiments competing interfering clones of bacteriophage infecting a bacterium support the model prediction that the clones are unable to invade each other from rare. We briefly discuss the implications of these results for host-parasite ecology and (co)evolution. en
dc.description.sponsorship Royal Society - Science Foundation Ireland (University Research Fellowship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.rights © 2017, Cambridge University Press. All rights reserved. en
dc.subject Multiplicity of infection en
dc.subject MOI en
dc.subject Interference competition en
dc.subject Positive frequency dependence en
dc.subject Bacteria en
dc.subject Phage en
dc.title Within-host interference competition can prevent invasion of rare parasites en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Pauline Scanlan, Alimentary Pharmabotic Centre (Apc), University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.scanlan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-09-19T09:18:32Z
dc.description.version Accepted Version en
dc.internal.rssid 443435067
dc.internal.pmid 28502267
dc.contributor.funder Natural Environment Research Council en
dc.contributor.funder Biotechnology and Biological Sciences Research Council en
dc.contributor.funder AXA Research Fund en
dc.contributor.funder Royal Society en
dc.contributor.funder Royal Commission for the Exhibition of 1851 en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Parasitology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress p.scanlan@ucc.ie en
dc.identifier.eissn 1937-2345


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