Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants

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dc.contributor.author Togher, Katie L.
dc.contributor.author O'Keeffe, Gerard W.
dc.contributor.author Khashan, Ali S.
dc.contributor.author Clarke, Gerard
dc.contributor.author Kenny, Louise C.
dc.date.accessioned 2019-10-01T05:07:49Z
dc.date.available 2019-10-01T05:07:49Z
dc.date.issued 2018-10-11
dc.identifier.citation Togher, K.L., O’Keeffe, G.W., Khashan, A.S., Clarke, G. and Kenny, L.C., 2018. Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants. Scientific reports, 8(1), (15151). DOI:10.1038/s41598-018-33357-3 en
dc.identifier.volume 8 en
dc.identifier.issued 13 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10468/8636
dc.identifier.doi 10.1038/s41598-018-33357-3 en
dc.description.abstract Prenatal distress is associated with adverse outcomes in affected offspring. Alterations in placental glucocorticoid signalling and subsequent foetal overexposure to glucocorticoids have been implicated as an underlying mechanism. Infant sex is emerging as an important factor in disease susceptibility. This study aimed to examine the effects of maternal distress across pregnancy on birth outcomes and placental glucocorticoid genes in a sex-dependent manner. Participants completed psychological distress questionnaires throughout pregnancy. Placental HSD11B2, NR3C1 and FKBP51 were analysed by real time PCR and cortisol was measured in new-born hair. Second trimester stress was negatively correlated with birthweight in males and positively correlated with placental NR3C1 mRNA in females. Second trimester anxiety was negatively correlated with birthweight and placental FKBP51 mRNA in females. In mediation analysis, placental FKBP51 mRNA expression was found to mediate the link between prenatal anxiety and birthweight. New-born cortisol was negatively correlated with second trimester anxiety and positively correlated with female placental FKBP51 mRNA levels. Again, FKBP51 mRNA was found to mediate the link between anxiety and new-born cortisol. These results highlight a role for FKBP51 in the placental response to prenatal distress in females. The precise role that placental FKBP51 has in foetal and infant development has not been extensively studied and warrants further investigations. en
dc.description.sponsorship INFANT Centre; Microbiome Institute en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Ltd en
dc.relation.uri https://www.nature.com/articles/s41598-018-33357-3
dc.rights © The Author(s) 2018 en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Prenatal en
dc.subject Maternal anxiety en
dc.subject Birthweight en
dc.title Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.identifier.articleid 15151 en
dc.identifier.eissn 2045-2322


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© The Author(s) 2018 Except where otherwise noted, this item's license is described as © The Author(s) 2018
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