The impact of caesarean section on the risk of childhood overweight and obesity: new evidence from a contemporary cohort study

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Show simple item record Masukume, Gwinyai O'Neill, Sinéad M. Baker, Philip N. Kenny, Louise C. Morton, Susan M. B. Khashan, Ali S. 2019-10-01T05:08:04Z 2019-10-01T05:08:04Z 2018-10-11
dc.identifier.citation Masukume, G., O’Neill, S.M., Baker, P.N., Kenny, L.C., Morton, S.M. and Khashan, A.S., 2018. The Impact of Caesarean Section on the Risk of Childhood Overweight and Obesity: New Evidence from a Contemporary Cohort Study. Scientific reports, 8(1),(15113). DOI:10.1038/s41598-018-33482-z en
dc.identifier.volume 8 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.issn 2045-2322
dc.identifier.doi 10.1038/s41598-018-33482-z en
dc.description.abstract Caesarean section (CS) rates are increasing globally and exceed 50% in some countries. Childhood obesity has been linked to CS via lack of exposure to vaginal microflora although the literature is inconsistent. We investigated the association between CS birth and the risk of childhood obesity using the nationally representative Growing-Up-in-Ireland (GUI) cohort. The GUI study recruited randomly 11134 infants. The exposure was categorised into normal vaginal birth (VD) [reference], assisted VD, elective (planned) CS and emergency (unplanned) CS. The primary outcome measure was obesity defined according to the International Obesity Taskforce criteria. Statistical analysis included multinomial logistic regression with adjustment for potential confounders. Infants delivered by elective CS had an adjusted relative risk ratio (aRRR) = 1.32; [95% confidence interval (CI) 1.01–1.74] of being obese at age three years. This association was attenuated when macrosomic children were excluded (aRRR = 0.99; [95% CI 0.67–1.45]). Infants delivered by emergency CS had an increased risk of obesity aRRR = 1.56; [95% CI 1.20–2.03]; this association remained after excluding macrosomic children. We found insufficient evidence to support a causal relationship between elective CS and childhood obesity. An increased risk of obesity in children born by emergency CS, but not elective, suggests that there is no causal effect due to vaginal microflora. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Ltd en
dc.rights © The Author(s) 2018 en
dc.rights.uri en
dc.subject Caesarean section (CS) en
dc.subject Childhood obesity en
dc.subject Vaginal microflora en
dc.title The impact of caesarean section on the risk of childhood overweight and obesity: new evidence from a contemporary cohort study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ali Khashan, School of Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Department of Children and Youth Affairs en
dc.contributor.funder Trinity College Dublin en
dc.contributor.funder Economic and Social Research Institute en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.IRISemailaddress en
dc.identifier.articleid 15113 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en

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