A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations

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dc.contributor.author Cashman, Kevin D.
dc.contributor.author Fitzgerald, Anthony P.
dc.contributor.author Kiely, Mairead E.
dc.contributor.author Seamans, Kelly M.
dc.date.accessioned 2012-12-20T15:40:54Z
dc.date.available 2012-12-20T15:40:54Z
dc.date.copyright 2011
dc.date.issued 2011-12
dc.identifier.citation Cashman, K. D.,Fitzgerald, A. P.,Kiely, M.,Seamans, K. M. (2011) 'A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations'. British Journal of Nutrition, 106 (11), 1638–1648. doi:10.1017/S0007114511005058 en
dc.identifier.volume 106 en
dc.identifier.issued 11 en
dc.identifier.startpage 1638 en
dc.identifier.endpage 1648 en
dc.identifier.issn 1475-2662
dc.identifier.uri http://hdl.handle.net/10468/863
dc.identifier.doi 10.1017/S0007114511005058
dc.description.abstract The present study used a systematic review approach to identify relevant randomised control trials (RCT) with vitamin D and then apply meta-regression to explore the most appropriate model of the vitamin D intake–serum 25-hydroxyvitamin D (25(OH)D) relationship to underpin setting reference intake values. Methods included an updated structured search on Ovid MEDLINE; rigorous inclusion/exclusion criteria; data extraction; and meta-regression (using different model constructs). In particular, priority was given to data from winter-based RCT performed at latitudes >49•58°N (n 12). A combined weighted linear model meta-regression analyses of natural log (Ln) total vitamin D intake (i.e. diet and supplemental vitamin D) versus achieved serum 25(OH)D in winter (that used by the North American Dietary Reference Intake Committee) produced a curvilinear relationship (mean (95% lower CI) serum 25(OH)D (nmol/l) = 9•2 (8•5) Ln (total vitamin D)). Use of non-transformed total vitamin D intake data (maximum 1400 IU/d; 35µg/d) provided for a more linear relationship (mean serum 25(OH)D (nmol/l) = 0•044 × (total vitamin D) + 33•035). Although inputting an intake of 600 IU/d (i.e. the RDA) into the 95% lower CI curvilinear and linear models predicted a serum 25(OH)D of 54•4 and 55•2 nmol/l, respectively, the total vitamin D intake that would achieve 50 (and 40) nmol/l serum 25(OH)D was 359 (111) and 480 (260) IU/d, respectively. Inclusion of 95% range in the model to account for inter-individual variability increased the predicted intake of vitamin D needed to maintain serum 25(OH)D ≥50 nmol/l to 930 IU/d. The model used to describe the vitamin D intake–status relationship needs to be considered carefully when setting new reference intake values in Europe. en
dc.description.sponsorship European Commission (specific RTD Programme ‘Quality of Life and Management of Living Resources’, within the 6th Framework Programme (contract no. FP6-036196-2 EURRECA: EURopean micronutrient RECommendations Aligned)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.rights © The Authors 2011 en
dc.subject Regression analysis en
dc.subject Systematic reviews en
dc.subject Vitamin D requirements en
dc.subject Serum 25-hydroxyvitamin D en
dc.subject European Micronutrient Recommendations Aligned (EURRECA) en
dc.title A systematic review and meta-regression analysis of the vitamin D intake-serum 25-hydroxyvitamin D relationship to inform European recommendations en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://publish.ucc.ie/researchprofiles/C010/tfitzgerald en
dc.internal.authorcontactother Tony Fitzgerald, Epidemiology & Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.fitzgerald@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2012-12-19T16:01:19Z
dc.description.version Published Version en
dc.internal.rssid 117125756
dc.contributor.funder Sixth Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle British Journal of Nutrition en
dc.internal.copyrightchecked Yes. CORA - ROMEO - Published Version permitted 12 months after publication. en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication Cambridge en
dc.internal.IRISemailaddress t.fitzgerald@ucc.ie en


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