Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice

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dc.contributor.author Di Paola, Monica
dc.contributor.author Bonechi, Elena
dc.contributor.author Provensi, Gustavo
dc.contributor.author Costa, Alessia
dc.contributor.author Clarke, Gerard
dc.contributor.author Ballerini, Clara
dc.contributor.author De Filippo, Carlotta
dc.contributor.author Passani, M. Beatrice
dc.date.accessioned 2019-10-02T04:36:26Z
dc.date.available 2019-10-02T04:36:26Z
dc.date.issued 2018-10-05
dc.identifier.citation Di Paola, M., Bonechi, E., Provensi, G., Costa, A., Clarke, G., Ballerini, C., De Filippo, C. and Passani, M.B., 2018. Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice. Scientific reports, 8(1), (14881). DOI:10.1038/s41598-018-32925-x en
dc.identifier.volume 8 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.uri http://hdl.handle.net/10468/8658
dc.identifier.doi 10.1038/s41598-018-32925-x en
dc.description.abstract The lipid sensor oleoylethanolamide (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-inflammatory activity, stimulation of lipolysis and fatty acid oxidation. When administered exogenously, OEA has beneficial effects in several cognitive paradigms; therefore, in all respects, OEA can be considered a hormone of the gut-brain axis. Here we report an unexplored modulatory effect of OEA on the intestinal microbiota and on immune response. Our study shows for the first time that sub-chronic OEA administration to mice fed a normal chow pellet diet, changes the faecal microbiota profile, shifting the Firmicutes:Bacteroidetes ratio in favour of Bacteroidetes (in particular Bacteroides genus) and decreasing Firmicutes (Lactobacillus), and reduces intestinal cytokines expression by immune cells isolated from Peyer’s patches. Our results suggest that sub-chronic OEA treatment modulates gut microbiota composition towards a “lean-like phenotype”, and polarises gut-specific immune responses mimicking the effect of a diet low in fat and high in polysaccharides content. en
dc.description.sponsorship 201511/2014-2; GR-201102346829 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature Limited en
dc.relation.uri https://www.nature.com/articles/s41598-018-32925-x
dc.rights © The Author(s) 2018 en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Oleoylethanolamide (OEA) en
dc.subject Peroxisome proliferator-activated receptor-α (PPAR-α) en
dc.subject Proximal intestine en
dc.subject Cognitive paradigms en
dc.title Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, Department of Psychiatry and Neurobehavioural Science and APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.clarke@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Joint Programming Initiative A healthy diet for a healthy life en
dc.contributor.funder Conselho Nacional de Desenvolvimento Científico e Tecnológico en
dc.contributor.funder Ministero della Salute en
dc.contributor.funder Bando Ricerca Finalizzata en
dc.contributor.funder Giovani Ricercatori en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.IRISemailaddress g.clarke@ucc.ie en
dc.identifier.articleid 14881 en
dc.relation.project info:eu-repo/grantAgreement/RCUK/MRC/MR/N029488/1/GB/AMBROSIAC - A Menu for Brain Responses Opposing Stress-Induced Alterations in Cognition/ en
dc.identifier.eissn 2045-2322

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