Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

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dc.contributor.author Miller, Charlotte M.
dc.contributor.author O'Sullivan, Elaine C.
dc.contributor.author McCarthy, Florence O.
dc.date.accessioned 2019-10-06T20:34:29Z
dc.date.available 2019-10-06T20:34:29Z
dc.date.issued 2019-06-14
dc.identifier.citation Miller, C. M., O’Sullivan, E. C. and McCarthy, F. O. (2019) 'Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells', Pharmaceuticals, 12(2), 90 (15pp). DOI: 10.3390/ph12020090 en
dc.identifier.volume 12 en
dc.identifier.issued 2 en
dc.identifier.startpage 1 en
dc.identifier.endpage 15 en
dc.identifier.uri http://hdl.handle.net/10468/8692
dc.identifier.doi 10.3390/ph12020090 en
dc.description.abstract Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects. en
dc.description.sponsorship Irish Research Council and the Higher Education Authority of Ireland (PRTLI4 programme) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI AG en
dc.relation.uri https://www.mdpi.com/1424-8247/12/2/90/htm
dc.rights © The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Ellipticine en
dc.subject Anticancer en
dc.subject Heterocycli chemistry en
dc.subject Indole en
dc.subject NCI screen en
dc.subject Topoisomerase II en
dc.title Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Florence O. McCarthy, School of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland. +353-21-490-3000 Email:f.mccarthy@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Irish Research Council en
dc.contributor.funder Higher Education Authority en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pharmaceuticals en
dc.internal.IRISemailaddress f.mccarthy@ucc.ie en
dc.identifier.articleid 90 en
dc.identifier.eissn 1424-8247


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© The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Except where otherwise noted, this item's license is described as © The Author(s) 2019. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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