Gut microbiota alterations associated with reduced bone mineral density in older adults

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dc.contributor.author Das, Mrinmoy
dc.contributor.author Cronin, Owen
dc.contributor.author Keohane, David M.
dc.contributor.author Cormac, Edel M.
dc.contributor.author Nugent, Helena
dc.contributor.author Nugent, Michelle
dc.contributor.author Molloy, Catherine
dc.contributor.author O'Toole, Paul W.
dc.contributor.author Shanahan, Fergus
dc.contributor.author Molloy, Michael G.
dc.contributor.author Jeffery, Ian B.
dc.date.accessioned 2019-10-06T20:39:07Z
dc.date.available 2019-10-06T20:39:07Z
dc.date.issued 2019-08-04
dc.identifier.citation Das, M., Cronin, O., Keohane, D. M., Cormac, E. M., Nugent, H., Nugent, M., Molloy, C., O’Toole, P. W., Shanahan, F., Molloy, M. G. and Jeffery, I. B. (2019) 'Gut microbiota alterations associated with reduced bone mineral density in older adults', Rheumatology, kez302 (10pp) [In press]. DOI: 10.1093/rheumatology/kez302 en
dc.identifier.startpage 1 en
dc.identifier.endpage 10 en
dc.identifier.issn 1462-0324
dc.identifier.uri http://hdl.handle.net/10468/8695
dc.identifier.doi 10.1093/rheumatology/kez302 en
dc.description.abstract Objective: To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults. Methods: Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60). Analysis of the 16S (V3-V4 region) amplicon dataset classified to the genus level was used to identify significantly differentially abundant taxa. Adjustments were made for potential confounding variables identified from the literature using several statistical models. Results: We identified six genera that were significantly altered in abundance in the osteoporosis or osteopenic groups compared with age- and gender-matched controls. A detailed study of microbiota associations with meta-data variables that included BMI, health status, diet and medication revealed that these meta-data explained 15–17% of the variance within the microbiota dataset. BMD measurements were significantly associated with alterations in the microbiota. After controlling for known biological confounders, five of the six taxa remained significant. Overall microbiota alpha diversity did not correlate to BMD in this study. Conclusion: Reduced BMD in osteopenia and osteoporosis is associated with an altered microbiota. These alterations may be useful as biomarkers or therapeutic targets in individuals at high risk of reductions in BMD. These observations will lead to a better understanding of the relationship between the microbiota and bone homeostasis. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher British Society of Rheumatology en
dc.relation.uri https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/kez302/5543609
dc.rights ©The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Osteoporosis en
dc.subject Gut microbiota en
dc.subject Bone mineral density en
dc.subject Elderly en
dc.subject Osteopenia en
dc.title Gut microbiota alterations associated with reduced bone mineral density in older adults en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ian B Jeffery, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email:i.jeffery@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder icare en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Rheumatology en
dc.internal.IRISemailaddress i.jeffery@ucc.ie en
dc.identifier.articleid kez302 en
dc.internal.bibliocheck Check Vol, issue and page range en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/ en


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©The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Except where otherwise noted, this item's license is described as ©The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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