A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery

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dc.contributor.author O'Mahony, Aoife M.
dc.contributor.author Ogier, Julien R.
dc.contributor.author Desgranges, Stephane
dc.contributor.author Cryan, John F.
dc.contributor.author Darcy, Raphael
dc.contributor.author O'Driscoll, Caitríona M.
dc.date.accessioned 2013-01-09T10:31:02Z
dc.date.available 2013-01-09T10:31:02Z
dc.date.copyright 2012
dc.date.issued 2012-05-21
dc.identifier.citation O'Mahony, A.M.,Ogier, J.,Desgranges, S.,Cryan, J.F.,Darcy, R.,O'Driscoll, C.M. (2012) 'A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery'. Organic & Biomolecular Chemistry, 10 :4954-4960. doi: 10.1039/c2ob25490e en
dc.identifier.volume 10 en
dc.identifier.startpage 4954 en
dc.identifier.endpage 4960 en
dc.identifier.issn 1477-0520
dc.identifier.issn 1477-0539
dc.identifier.uri http://hdl.handle.net/10468/869
dc.identifier.doi 10.1039/c2ob25490e
dc.description.abstract A new approach to the synthesis of amphiphilic beta-cyclodextrins has used 'click' chemistry to selectively modify the secondary 2-hydroxyl group. The resulting extended polar groups can be either polycationic or neutral PEGylated groups and these two amphiphile classes are compatible in dual cyclodextrin formulations for delivery of siRNA. When used alone with an siRNA, a cationic cyclodextrin was shown to have good transfection properties in cell culture. Co-formulation with a PEGylated cyclodextrin altered the physicochemical properties of nanoparticles formed with siRNA. Improved particle properties included lower surface charges and reduced tendency to aggregate. However, as expected, the transfection efficiency of the cationic vector was lowered by co-formulation with the PEGylated cyclodextrin, requiring future surface modification of particles with targeting ligands for effective siRNA delivery. en
dc.description.sponsorship Science Foundation Ireland (Strategic Research Cluster grant no. 07/SRC/B1154), Irish Research Council for Science, Engineering and Technology (EMBARK initiative) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Royal Society of Chemistry en
dc.rights © The Royal Society of Chemistry 2012 en
dc.subject Gene delivery en
dc.subject Chain-length en
dc.subject Nanoparticles en
dc.subject Particles en
dc.subject Vectors en
dc.subject Trafficking en
dc.subject Polyplexes en
dc.subject.lcsh Cyclodextrins en
dc.title A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://publish.ucc.ie/researchprofiles/C019/caitrionaodriscoll en
dc.internal.authorcontactother Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: caitriona.odriscoll@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2013-01-04T15:00:08Z
dc.description.version Accepted Version en
dc.internal.rssid 160747350
dc.internal.wokid 000304885200017
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Drug Delivery Network en
dc.contributor.funder Irish Research Council for Science, Engineering and Technology en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Organic & Biomolecular Chemistry en
dc.internal.copyrightchecked No !!CORA!! - ROMEO. RSC Accepted version and 12 month embargo en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication London en
dc.internal.IRISemailaddress caitriona.odriscoll@ucc.ie en


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