Cyclodextrins for non-viral gene and siRNA delivery

Show simple item record O'Mahony, Aoife M. O'Driscoll, Caitríona M. O'Neill, Martin J. Godinho, Bruno M. D. C. Darcy, Raphael Cryan, John F. 2013-01-09T12:00:54Z 2013-01-09T12:00:54Z 2013-01
dc.identifier.citation O'Mahony A.M., O Neill M.J., Godinho B.M.D.C., Darcy, R., Cryan, J.F.,O'Driscoll, C.M. (2013) 'Cyclodextrins for Non-Viral Gene and siRNA Delivery'. Pharmaceutical Nanotechnology, 1(1) pp. 6-14. doi: 10.2174/2211738511301010006 en
dc.identifier.volume 1 en
dc.identifier.issued 1 en
dc.identifier.startpage 6 en
dc.identifier.endpage 14 en
dc.identifier.issn 2211-7385
dc.identifier.issn 2211-7393
dc.identifier.doi 10.2174/2211738511301010006
dc.description.abstract Considerable research is focused on the development of non-viral vectors for gene and RNA interference therapies, with significant advancements in this field over the past number of years. Cationic lipids and polymers have been extensively investigated for these purposes, but there still remains a need for alternative vectors. Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch and are well characterised pharmaceutical excipients. They offer many advantages as potential non-viral vectors for gene and siRNA delivery, in particular the ease with which they can be chemically modified and their limited toxicity. In recent years, there has been a surge in the number of publications concerning CDs in this field. In this paper, we will review the two main approaches to the use of CDs for gene and siRNA delivery. In the first instance, CDs are used as a scaffold, to which various chemical groups can be grafted, yielding monodisperse functionalised CDs which can self-assemble in the presence of oligonucleotides. CDs are particularly amenable to chemical modification and this approach enables specific and precise design of CD vectors for targeting to various cell and tissue types. In the second approach, CDs can be included as a component of a delivery system, for example, as part of a polymer backbone, appended to a dendrimeric vector, or in polyrotaxane systems. Here, the inclusion of CDs facilitates post-modification of the vector through the formation of inclusion complexes with adamantane and, in some instances, reduces toxicity of the vector. Lastly, we will consider the development of in vivo CD vectors for therapeutic use and other novel applications including siRNA delivery in neurons and the CNS. en
dc.description.sponsorship Science Foundation Ireland (grant no. 07/SRC/B1154); Irish Research Council for Science Engineering and Technology (Embark initiative) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Bentham Science Publishers en
dc.rights Copyright © 2013 Bentham Science Publishers. All Rights Reserved. en
dc.subject siRNA en
dc.subject Click chemistry en
dc.subject Genes en
dc.subject Non-viral delivery en
dc.subject Pre-clinical en
dc.subject.lcsh Cyclodextrins en
dc.title Cyclodextrins for non-viral gene and siRNA delivery en
dc.type Article (peer-reviewed) en
dc.internal.authorurl en
dc.internal.authorcontactother Caitriona O'Driscoll, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text not available en 2013-01-04T14:55:58Z
dc.description.version Accepted Version en
dc.internal.rssid 184533871
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council for Science Engineering and Technology en
dc.contributor.funder Irish Drug Delivery Network en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pharmaceutical Nanotechnology en
dc.internal.copyrightchecked No - CORA - Yes. Accepted version permitted. Must link to journal homepage en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication Bussum, The Netherlands en
dc.internal.IRISemailaddress en

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