Microbial regulation of microRNA expression in the brain-gut axis

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dc.contributor.author Moloney, Gerard M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Clarke, Gerard
dc.contributor.author Cryan, John F.
dc.date.accessioned 2019-10-11T08:29:48Z
dc.date.available 2019-10-11T08:29:48Z
dc.date.issued 2019-10-04
dc.identifier.citation Moloney, G. M., Dinan, T. G., Clarke, G. and Cryan, J. F. (2019) 'Microbial regulation of microRNA expression in the brain-gut axis', Current Opinion in Pharmacology, 48, pp. 120-126. doi: 10.1016/j.coph.2019.08.005 en
dc.identifier.volume 48 en
dc.identifier.startpage 120 en
dc.identifier.endpage 126 en
dc.identifier.issn 1471-4892
dc.identifier.uri http://hdl.handle.net/10468/8739
dc.identifier.doi 10.1016/j.coph.2019.08.005 en
dc.description.abstract The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine how these small non-coding RNAs influence the gut microbiome, and secondly how the microbiome, when disturbed, may influence miRNA expression in the brain. In addition, we will examine the consequence that microbiome-related changes in miRNA expression have on neurodevelopment, behaviour and cognition. We will also discuss novel data that suggests miRNAs contained in our diet may influence our immune system in a positive manner, offering a further potential pathway for treatment of disorders of the gutâ brain axis that are influenced by the microbiome. en
dc.description.sponsorship Health Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd. en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1471489219300748
dc.rights © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject MicroRNA en
dc.subject Gut microbiome en
dc.subject MiRNA en
dc.subject Neurodevelopment en
dc.subject Behaviour en
dc.subject Cognition en
dc.subject Diet en
dc.subject Immune system en
dc.title Microbial regulation of microRNA expression in the brain-gut axis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Moloney, Anatomy and Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.moloney@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2020-10-04
dc.date.updated 2019-10-11T08:19:31Z
dc.description.version Accepted Version en
dc.internal.rssid 499904876
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Air Force Office of Scientific Research en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Current Opinion In Pharmacology en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.moloney@ucc.ie en
dc.internal.IRISemailaddress t.dinan@ucc.ie
dc.internal.IRISemailaddress g.clarke@ucc.ie
dc.internal.IRISemailaddress j.cryan@ucc.ie
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1471-4973


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© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence. Except where otherwise noted, this item's license is described as © 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence.
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