Bifidobacterial transfer from mother to child as examined by an animal model

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Mancino, Walter
Duranti, Sabrina
Mancabelli, Leonardo
Longhi, Giulia
Anzalone, Rosaria
Milani, Christian
Lugli, Gabriele Andrea
Carnevali, Luca
Statello, Rosario
Sgoifo, Andrea
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Bifidobacteria commonly constitute the most abundant group of microorganisms in the healthy infant gut. Their intestinal establishment is believed to be maternally driven, and their acquisition has even been postulated to occur during pregnancy. In the current study, we evaluated bifidobacterial mother-to infant transmission events in a rat model by means of quantitative PCR (qPCR), as well as by Internally Transcribed Spacer (ITS) bifidobacterial profiling. The occurrence of strains supplied by mothers during pregnancy to their corresponding newborns was observed and identified by analysis immediately following C-section delivery. These findings provide intriguing support for the existence of an unknown route to facilitate bifidobacterial transfer during the very early stages of life.
Bifidobacteria , Infant gut microbiota , Microbe-host coevolution , Metagenomics
Mancino, W., Duranti, S., Mancabelli, L., Longhi, G., Anzalone, R., Milani, C., Lugli, G. A., Carnevali, L., Statello, R., Sgoifo, A., van Sinderen, D., Ventura, M. and Turroni, F. (2019) 'Bifidobacterial Transfer from Mother to Child as Examined by an Animal Model', Microorganisms, 7(9), 293 (13pp.). DOI: 10.3390/microorganisms7090293