Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury
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Published version
Supplementary file 1
Date
2018-08-30
Authors
Duranti, Sabrina
Vivo, Valentina
Zini, Irene
Milani, Christian
Mangifesta, Marta
Anzalone, Rosaria
Mancabelli, Leonardo
Viappiani, Alice
Cantoni, Anna Maria
Barocelli, Elisabetta
Journal Title
Journal ISSN
Volume Title
Publisher
PLoS
Published Version
Abstract
Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.
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Keywords
Intestinal ischemia/reperfusion injury , Gut microbiome , Bifidobacterium bifidum PRL2010 , Human health
Citation
Duranti, S., Vivo, V., Zini, I., Milani, C., Mangifesta, M., Anzalone, R., Mancabelli, L., Viappiani, A., Cantoni, A.M., Barocelli, E. and van Sinderen, D., 2018. Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury. PloS one, 13(8), e0202670, (16 pp.). DOI:10.1371/journal.pone.0202670