Is there potential for repurposing statins as novel antimicrobials?

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dc.contributor.author Hennessy, Emma
dc.contributor.author Adams, Claire
dc.contributor.author Reen, F. Jerry
dc.contributor.author O'Gara, Fergal
dc.date.accessioned 2019-11-05T17:06:13Z
dc.date.available 2019-11-05T17:06:13Z
dc.date.issued 2016-08-22
dc.identifier.citation Hennessy, E., Adams, C., Reen, F. J. and O'Gara, F. (2016) 'Is There Potential for Repurposing Statins as Novel Antimicrobials?', Antimicrobial Agents and Chemotherapy, 60(9), pp. 5111-5121. doi: 10.1128/AAC.00192-16 en
dc.identifier.volume 60 en
dc.identifier.issued 9 en
dc.identifier.startpage 5111 en
dc.identifier.endpage 21 en
dc.identifier.issn 1098-6596
dc.identifier.uri http://hdl.handle.net/10468/8956
dc.identifier.doi 10.1128/AAC.00192-16 en
dc.description.abstract Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, and antimicrobial effects. An increasing number of studies are emerging which detail the attenuation of bacterial growth and in vitro and in vivo virulence by statin treatment. In this review, we describe the current information available concerning the effects of statins on bacterial infections and provide insight regarding the potential use of these compounds as antimicrobial therapeutic agents. en
dc.description.sponsorship Health Research Board (HRB MRCG-2014-6) en
dc.description.sponsorship Teagasc (Walsh Fellowship 2013) en
dc.description.sponsorship Department of Agriculture, Food and the Marine (FIRM/RSF/CoFoRD, FIRM 08/RDC/629, FIRM 1/F009/MabS, and FIRM 13/F/516) en
dc.description.sponsorship Irish Research Council for Science, Engineering and Technology (PD/2011/2414 and GOIPG/2014/647)) en
dc.description.sponsorship Marine Institute ((Foras Na Mara) (Beaufort award C2CRA 2007/082)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Society for Microbiology en
dc.relation.uri https://aac.asm.org/content/60/9/5111.short
dc.rights © 2016, American Society for Microbiology. All Rights Reserved. en
dc.subject Anti-infective agents en
dc.subject Bacteremia en
dc.subject Bacterial toxins en
dc.subject Biofilms en
dc.subject Drug repositioning en
dc.subject Gram-negative bacteria en
dc.subject Gram-positive en
dc.subject Bacteria en
dc.subject Hydroxymethylglutaryl-CoA reductase inhibitors en
dc.subject Microbial sensitivity en
dc.subject Tests en
dc.subject Pneumonia, bacterial en
dc.subject Sepsis en
dc.subject Survival analysis en
dc.subject Virulence factors en
dc.title Is there potential for repurposing statins as novel antimicrobials? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergal O'Gara, Microbiology , University College Cork, Cork, Ireland. +353-21-490-3000 Email: f.ogara@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2019-11-05T17:00:27Z
dc.description.version Accepted Version en
dc.internal.rssid 419970622
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Health Research Board en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Food Institutional Research Measure en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Antimicrobial Agents and Chemotherapy, en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress f.ogara@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATION en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE en


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