Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response

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dc.contributor.author Frei, Remo
dc.contributor.author Roduit, Caroline
dc.contributor.author Ferstl, Ruth
dc.contributor.author O'Mahony, Liam
dc.contributor.author Lauener, Roger P.
dc.date.accessioned 2019-11-06T10:22:14Z
dc.date.available 2019-11-06T10:22:14Z
dc.date.issued 2019-07-16
dc.identifier.citation Frei, R., Roduit, C., Ferstl, R., O'Mahony, L. and Lauener, R. (2019) 'Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response', Frontiers in Immunology, 10, 1628 (5pp). doi:10.3389/fimmu.2019.01628 en
dc.identifier.volume 10 en
dc.identifier.startpage 1 en
dc.identifier.endpage 5 en
dc.identifier.uri http://hdl.handle.net/10468/8958
dc.identifier.doi 10.3389/fimmu.2019.01628 en
dc.description.abstract Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products that turned out to be important. These exposures provide contact to N-glycolylneuraminic acid (Neu5Gc), a sialic acid naturally expressed in mammalians but not in humans or microbes although both are able to incorporate exogenously provided Neu5Gc and induce thereby and anti-Neu5Gc antibody response. Farmers’ children had elevated levels of anti-Neu5Gc antibodies associated with increased contact to Neu5Gc. Farm-related exposures that were associated with protection against allergies such as exposure to farm-animals or pets and consumption of milk were also associated with an antibody response to Neu5Gc in children. Exposure to cats was associated with increased anit-Neu5Gc IgG levels at different timepoints assessed between one year of age and school-age. Moreover, consumption of non-pasteurized milk in the first year of life was associated with increased anti-Neu5Gc IgG levels. Neu5Gc-providing exposures that were associated with protection against allergies were reflected in an elevated anti-Neu5Gc IgG level in children. Exposure to Neu5Gc was associated with anti-inflammation and protection of asthma development in children and mice without contribution of anti-Neu5Gc antibodies. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2019 Frei, Roduit, Ferstl, O'Mahony and Lauener. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject N-glycolyl neuraminic acid en
dc.subject Asmtha en
dc.subject Regulatory T (Treg) cell en
dc.subject Anti-inflammation en
dc.subject Animal contact en
dc.subject Hygiene hypothesis en
dc.title Exposure of children to rural lifestyle factors associated with protection against allergies induces an anti-Neu5Gc antibody response en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Liam O'Mahony, Department of Medicine, University College Cork, Cork, Ireland. +353-21-490-3000 Email: liam.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Christine Kuehne-Center for Allergy Research and Education (CK-CARE), Switzerland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Immunology en
dc.internal.IRISemailaddress liam.omahony@ucc.ie en
dc.identifier.articleid 1628 en
dc.identifier.eissn 1664-3224


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© 2019 Frei, Roduit, Ferstl, O'Mahony and Lauener. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2019 Frei, Roduit, Ferstl, O'Mahony and Lauener. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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