The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions

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dc.contributor.author Jones, David J.
dc.contributor.author Lautens, Mark
dc.contributor.author McGlacken, Gerard P.
dc.date.accessioned 2019-11-15T13:03:36Z
dc.date.available 2019-11-15T13:03:36Z
dc.date.issued 2019-10-07
dc.identifier.citation Jones, D. J., Lautens, M. and McGlacken, G. P. (2019) 'The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions', Nature Catalysis, 2(10), pp. 843-851. doi: 10.1038/s41929-019-0361-0 en
dc.identifier.volume 2 en
dc.identifier.issued 10 en
dc.identifier.startpage 843 en
dc.identifier.endpage 851 en
dc.identifier.issn 2520-1158
dc.identifier.uri http://hdl.handle.net/10468/9016
dc.identifier.doi 10.1038/s41929-019-0361-0 en
dc.description.abstract Exploiting the reversibility of chemical processes is a long-standing tactic of organic chemists, and permeates most areas of the discipline. The notion that oxidative addition of Pd(0) to Ar–X bonds can be considered an irreversible process has been challenged, periodically, over the last 30 years. Recent examples of methodologies that harness the reversibility of oxidative addition reactions in catalytic processes have enabled access to challenging carbocyclic and heterocyclic scaffolds. This Perspective seeks to describe the development of these processes from the early proof-of-principle findings, and highlight key challenges that remain in this avenue of research. In particular, we draw attention to significant deficiencies that remain in the choice of suitable ligands and additives for these transformations. We conclude by describing how the concept of reversible oxidative addition has recently been exploited in the development of novel carbonylation reactions. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature en
dc.relation.uri https://www.nature.com/articles/s41929-019-0361-0
dc.rights © 2019, Springer Nature Limited. This is a post-peer-review, pre-copyedit version of an article published in Nature Catalysis. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41929-019-0361-0 en
dc.subject Cross-coupling reactions en
dc.subject Homogeneous catalysis en
dc.subject Synthetic chemistry methodology en
dc.subject Carbonylation en
dc.subject Addition reactions en
dc.subject Additives en
dc.subject Scaffolds en
dc.subject Statistical mechanics en
dc.subject Carbohalogenation en
dc.subject Carbonylation reactions en
dc.subject Catalytic process en
dc.subject Chemical process en
dc.subject Irreversible process en
dc.subject Oxidative addition reaction en
dc.subject Oxidative additions en
dc.subject Proof of principles en
dc.title The emergence of Pd-mediated reversible oxidative addition in cross coupling, carbohalogenation and carbonylation reactions en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard P. Mcglacken, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: g.mcglacken@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 6 months after publication by request of the publisher. en
dc.check.date 2020-04-07
dc.date.updated 2019-11-15T12:56:31Z
dc.description.version Accepted Version en
dc.internal.rssid 499913657
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nature Catalysis en
dc.internal.copyrightchecked No
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.mcglacken@ucc.ie en
dc.internal.IRISemailaddress davidjones@ucc.ie en


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