Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants

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dc.contributor.author O'Toole, John M.
dc.contributor.author Pavlidis, Elena
dc.contributor.author Korotchikova, Irina
dc.contributor.author Boylan, Geraldine B.
dc.contributor.author Stevenson, Nathan J.
dc.date.accessioned 2019-11-19T10:20:04Z
dc.date.available 2019-11-19T10:20:04Z
dc.date.issued 2019-03-19
dc.identifier.citation O’Toole, J.M., Pavlidis, E., Korotchikova, I., Boylan, G.B. and Stevenson, N.J., 2019. Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants. Scientific reports, 9(1), (4859). DOI:10.1038/s41598-019-41227-9 en
dc.identifier.volume 9 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.uri http://hdl.handle.net/10468/9064
dc.identifier.doi 10.1038/s41598-019-41227-9 en
dc.description.abstract For the premature newborn, little is known about changes in brain activity during transition to extra-uterine life. We aim to quantify these changes in relation to the longer-term maturation of the developing brain. We analysed EEG for up to 72 hours after birth from 28 infants born <32 weeks of gestation. These infants had favourable neurodevelopment at 2 years of age and were without significant neurological compromise at time of EEG monitoring. Quantitative EEG was generated using features representing EEG power, discontinuity, spectral distribution, and inter-hemispheric connectivity. We found rapid changes in cortical activity over the 3 days distinct from slower changes associated with gestational age: for many features, evolution over 1 day after birth is equivalent to approximately 1 to 2.5 weeks of maturation. Considerable changes in the EEG immediately after birth implies that postnatal adaption significantly influences cerebral activity for early preterm infants. Postnatal age, in addition to gestational age, should be considered when analysing preterm EEG within the first few days after birth. en
dc.description.sponsorship 15/SIRG/3580; H2020-MCSA-IF-656131 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Nature en
dc.relation.uri https://www.nature.com/articles/s41598-019-41227-9
dc.rights © The Author(s) 2019 en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject EEG en
dc.subject Premature newborn en
dc.subject Brain activity en
dc.title Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John O'Toole, Department of Paediatrics and Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: jotoole@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.identifier.articleid 4859 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.identifier.eissn 2045-2322

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