Placental ageing in adverse pregnancy outcomes: Telomere shortening, cell senescence, and mitochondrial dysfunction

Show simple item record Manna, Samprikta McCarthy, Cathal McCarthy, Fergus P. 2019-11-20T05:26:38Z 2019-11-20T05:26:38Z 2019-05-22
dc.identifier.citation Manna, S., McCarthy, C. and McCarthy, F.P., 2019. Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction. Oxidative Medicine and Cellular Longevity, 2019. (11pp). DOI:10.1155/2019/3095383 en
dc.identifier.volume 2019 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.issn 1942-0900
dc.identifier.doi 10.1155/2019/3095383 en
dc.description.abstract Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia remains unclear; however, it is speculated that the various pathologies can be attributed to impaired vascular remodelling and elevated oxidative stress within the placenta. Oxidative stress plays a key role in cell ageing, and the persistent presence of elevated oxidative stress precipitates cellular senescence and mitochondrial dysfunction, resulting in premature ageing of the placenta. Premature ageing of the placenta is associated with placental insufficiency, which reduces the functional capacity of this critical organ and leads to abnormal pregnancy outcomes. The changes brought about by oxidative insults are irreversible and often lead to deleterious modifications in macromolecules such as lipids and proteins, DNA mutations, and alteration of mitochondrial functioning and dynamics. In this review, we have summarized the current knowledge of placental ageing in the aetiology of adverse pregnancy outcomes and discussed the hallmarks of ageing which could be potential markers for preeclampsia and fetal growth restriction. en
dc.description.sponsorship Marie Skłodowska-Curie Actions Innovative Training Network en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Hindawi en
dc.rights © 2019 Samprikta Manna et al en
dc.rights.uri en
dc.subject Preeclampsia en
dc.subject Neonatal morbidity en
dc.subject Neonatal mortality en
dc.subject Placental ageing en
dc.title Placental ageing in adverse pregnancy outcomes: Telomere shortening, cell senescence, and mitochondrial dysfunction en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Cathal McCarthy, Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Oxidative Medicine and Cellular Longevity en
dc.internal.IRISemailaddress en
dc.identifier.articleid 3095383 en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/765274/EU/Innovation in modelling Placenta for Maternal and Fetal Health/iPLACENTA en
dc.identifier.eissn 1942-0994

Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2019 Samprikta Manna et al Except where otherwise noted, this item's license is described as © 2019 Samprikta Manna et al
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement