Evaluation of phage therapy in the context of Enterococcus faecalis and its associated diseases

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dc.contributor.author Boloca, Andrei S.
dc.contributor.author Upadrasta, Aditya
dc.contributor.author de Almeida Bettio, Pedro H.
dc.contributor.author Clooney, Adam G.
dc.contributor.author Draper, Lorraine A.
dc.contributor.author Ross, R. Paul
dc.contributor.author Hill, Colin
dc.date.accessioned 2019-11-20T05:48:52Z
dc.date.available 2019-11-20T05:48:52Z
dc.date.issued 2019-04-20
dc.identifier.citation Bolocan, A.S., Upadrasta, A., Bettio, P.H., Clooney, A.G., Draper, L.A., Ross, R.P. and Hill, C., 2019. Evaluation of phage therapy in the context of Enterococcus faecalis and its associated diseases, Viruses, 11(4), (366). DOI:10.3390/v11040366 en
dc.identifier.volume 11 en
dc.identifier.issued 4 en
dc.identifier.startpage 1 en
dc.identifier.endpage 18 en
dc.identifier.issn 1999-4915
dc.identifier.uri http://hdl.handle.net/10468/9140
dc.identifier.doi 10.3390/v11040366 en
dc.description.abstract Bacteriophages (phages) or bacterial viruses have been proposed as natural antimicrobial agents to fight against antibiotic-resistant bacteria associated with human infections. Enterococcus faecalis is a gut commensal, which is occasionally found in the mouth and vaginal tract, and does not usually cause clinical problems. However, it can spread to other areas of the body and cause life-threatening infections, such as septicemia, endocarditis, or meningitis, in immunocompromised hosts. Although E. faecalis phage cocktails are not commercially available within the EU or USA, there is an accumulated evidence from in vitro and in vivo studies that have shown phage efficacy, which supports the idea of applying phage therapy to overcome infections associated with E. faecalis. In this review, we discuss the potency of bacteriophages in controlling E. faecalis, in both in vitro and in vivo scenarios. E. faecalis associated bacteriophages were compared at the genome level and an attempt was made to categorize phages with respect to their suitability for therapeutic application, using orthocluster analysis. In addition, E. faecalis phages have been examined for the presence of antibiotic-resistant genes, to ensure their safe use in clinical conditions. Finally, the domain architecture of E. faecalis phage-encoded endolysins are discussed. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri https://www.mdpi.com/1999-4915/11/4/366
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Phage therapy en
dc.subject E. faecalis en
dc.subject OrthoMCL en
dc.title Evaluation of phage therapy in the context of Enterococcus faecalis and its associated diseases en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colin Hill, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.hill@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Regional Development Fund en
dc.contributor.funder Janssen Biotech en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Viruses en
dc.internal.IRISemailaddress c.hill@ucc.ie en
dc.identifier.articleid 366 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/ en

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland
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