Dietary inflammatory index and biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis in adults

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dc.contributor.author Phillips, Catherine M.
dc.contributor.author Shivappa, Nitin
dc.contributor.author Hébert, James R.
dc.contributor.author Perry, Ivan J.
dc.date.accessioned 2019-11-23T07:04:37Z
dc.date.available 2019-11-23T07:04:37Z
dc.date.issued 2018-08-08
dc.identifier.citation Phillips, C., Shivappa, N., Hébert, J. and Perry, I. (2018) 'Dietary inflammatory index and biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis in adults'. Nutrients, 10(8), 1033. (13 pp.) doi:10.3390/nu10081033 en
dc.identifier.volume 10 en
dc.identifier.issued 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 13 en
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10468/9202
dc.identifier.doi 10.3390/nu10081033 en
dc.description.abstract Accumulating evidence identifies diet and inflammation as potential mechanisms contributing to cardiometabolic risk. However, inconsistent reports regarding dietary inflammatory potential, biomarkers of cardiometabolic health and metabolic syndrome (MetS) risk exist. Our objective was to examine the relationships between a food frequency questionnaire (FFQ)-derived dietary inflammatory index (DII®), biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis and MetS risk in a cross-sectional sample of 1992 adults. Energy-adjusted DII (E-DII) scores derived from an FFQ were calculated. Lipoprotein particle size and subclass concentrations were measured using nuclear magnetic resonance (NMR) spectroscopy. Serum acute-phase reactants, adipocytokines, pro-inflammatory cytokines and white blood cell (WBC) counts were determined. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Our data indicate that a more pro-inflammatory diet, reflected by higher E-DII scores, was associated with potentially pro-atherogenic lipoprotein profiles characterised by increased numbers of large very low density lipoprotein (VLDL), small dense low density lipoprotein (LDL) and high density lipoprotein (HDL) particles and less large LDL and HDL particles (all p < 0.001). Inflammatory profiling identified a range of adverse phenotypes among those with higher E-DII scores, including higher complement component C3 (C3), C-reactive protein (CRP), (both p < 0.05), interleukin 6 (IL-6) and tumour necrosis factor (TNF)-α concentrations, higher WBC counts and neutrophil to lymphocyte ratio (NLR) and lower adiponectin levels (all p < 0.001). MetS risk was increased among those with higher E-DII scores (OR 1.37, 95% CI (1.01, 1.88), p < 0.05), after adjusting for potential confounders. In conclusion, habitual intake of a more pro-inflammatory diet is associated with unfavourable lipoprotein and inflammatory profiles and increased MetS risk. en
dc.description.sponsorship Health Research Board (HRC/2007/13); Irish Heart Foundation (Noel Hickey Bursary supported by an educational grant from Pfizer Healthcare Ireland to CMP); National Institute of Diabetes and Digestive and Kidney Diseases (R44DK103377) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri https://www.mdpi.com/2072-6643/10/8/1033
dc.rights © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Inflammation en
dc.subject Dietary inflammation index en
dc.subject Metabolic syndrome en
dc.subject Lipoproteins en
dc.subject Adipocytokines en
dc.subject Pro-inflammatory cytokines en
dc.title Dietary inflammatory index and biomarkers of lipoprotein metabolism, inflammation and glucose homeostasis in adults en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ivan Perry, School of Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: i.perry@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Health Research Board en
dc.contributor.funder Irish Heart Foundation en
dc.contributor.funder National Institute of Diabetes and Digestive and Kidney Diseases en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nutrients en
dc.internal.IRISemailaddress i.perry@ucc.ie en
dc.identifier.articleid 1033 en


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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