In silico prediction and exploration of potential bacteriocin gene clusters within the bacterial genus Geobacillus

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dc.contributor.author Egan, Kevin
dc.contributor.author Field, Des
dc.contributor.author Ross, R. Paul
dc.contributor.author Cotter, Paul D.
dc.contributor.author Hill, Colin
dc.date.accessioned 2019-11-25T20:17:07Z
dc.date.available 2019-11-25T20:17:07Z
dc.date.issued 2018-09-20
dc.identifier.citation Egan, K., Field, D., Ross, R.P., Cotter, P.D. and Hill, C. (2018) 'In silico Prediction and Exploration of Potential Bacteriocin Gene Clusters within the bacterial genus Geobacillus'. Frontiers in microbiology, 9, 2116. (17pp). doi:10.3389/fmicb.2018.02116 en
dc.identifier.volume 9 en
dc.identifier.startpage 1 en
dc.identifier.endpage 17 en
dc.identifier.uri http://hdl.handle.net/10468/9219
dc.identifier.doi 10.3389/fmicb.2018.02116 en
dc.description.abstract The thermophilic, endospore-forming genus of Geobacillus has historically been associated with spoilage of canned food. However, in recent years it has become the subject of much attention due its biotechnological potential in areas such as enzyme and biofuel applications. One aspect of this genus that has not been fully explored or realised is its use as a source of novel forms of the ribosomally synthesised antimicrobial peptides known as bacteriocins. To date only two bacteriocins have been fully characterised within this genus, i.e., Geobacillin I and II, with only a small number of others partially characterised. Here we bioinformatically investigate the potential of this genus as a source of novel bacteriocins through the use of the in silico screening software BAGEL3, which scans publically available genomes for potential bacteriocin gene clusters. In this study we examined the association of bacteriocin gene presence with niche and phylogenetic position within the genus. We also identified a number of candidates from multiple bacteriocin classes which may be promising antimicrobial candidates when investigated in vitro in future studies. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (National Development Plan, through the Food Institutional Research Measure, administered by the Department of Agriculture, Fisheries and Food, Ireland 13/F/462) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fmicb.2018.02116
dc.rights © 2018 Egan, Field, Ross, Cotter and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Bacteriocin en
dc.subject Antimicrobial en
dc.subject Bioinformatic en
dc.subject In silico screening en
dc.subject Geobacillus en
dc.title In silico prediction and exploration of potential bacteriocin gene clusters within the bacterial genus Geobacillus en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colin Hill, School of Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.hill@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress c.hill@ucc.ie en
dc.identifier.articleid 2116 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B3027/IE/Lantibiotics: the next generation/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1664-302X


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© 2018 Egan, Field, Ross, Cotter and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2018 Egan, Field, Ross, Cotter and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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