Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

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dc.contributor.author Cronin, Owen
dc.contributor.author Barton, Wiley
dc.contributor.author Moran, Carthage
dc.contributor.author Sheehan, Donal
dc.contributor.author Whiston, Ronan
dc.contributor.author Nugent, Helena
dc.contributor.author McCarthy, Yvonne
dc.contributor.author Molloy, Catherine B.
dc.contributor.author O'Sullivan, Orla
dc.contributor.author Cotter, Paul D.
dc.contributor.author Molloy, Michael G.
dc.contributor.author Shanahan, Fergus
dc.date.accessioned 2019-11-26T05:06:40Z
dc.date.available 2019-11-26T05:06:40Z
dc.date.issued 2019-02-12
dc.identifier.citation Cronin, O., Barton, W., Moran, C., Sheehan, D., Whiston, R., Nugent, H., McCarthy, Y., Molloy, C.B., O’Sullivan, O., Cotter, P.D., Molloy, M.G. and Shanahan F. (2019) 'Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial' BMC Gastroenterology, 19(1), 29. (11pp) doi:10.1186/s12876-019-0952-x en
dc.identifier.volume 19 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 11 en
dc.identifier.uri http://hdl.handle.net/10468/9223
dc.identifier.doi 10.1186/s12876-019-0952-x en
dc.description.abstract Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 ± 6.5 years and Body Mass Index of 28.9 ± 3.8 were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. Results: Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the α- and β-diversity of gut microbiota and associated metabolic pathways were evident. Conclusions: Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central Ltd en
dc.relation.uri https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-0952-x
dc.rights © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Clinical trials en
dc.subject Microbiome en
dc.subject Exercise en
dc.subject Body composition en
dc.title Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergus Shanahan, Department of Medicine, University College Cork, Cork, Ireland. +353-21-490-3000 Email: f.shanahan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Centre for Arthritis Research and Education, Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Gastroenterology en
dc.internal.IRISemailaddress f.shanahan@ucc.ie en
dc.identifier.articleid 29 en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/11/PI/1137/IE/Obesibiotics/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2160/IE/Investigating the impact of high intensity exercise and/or protein intake levels on gut microbial diversity./ en
dc.identifier.eissn 1471-230X


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© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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