Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe

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dc.contributor.author Ryan, Paul M.
dc.contributor.author Stolte, Ellen H.
dc.contributor.author London, Lis E. E.
dc.contributor.author Wells, Jerry M.
dc.contributor.author Long, Sarah L.
dc.contributor.author Joyce, Susan A.
dc.contributor.author Gahan, Cormac G. M.
dc.contributor.author Fitzgerald, Gerald F.
dc.contributor.author Ross, R. Paul
dc.contributor.author Caplice, Noel M.
dc.contributor.author Stanton, Catherine
dc.date.accessioned 2019-11-26T05:59:28Z
dc.date.available 2019-11-26T05:59:28Z
dc.date.issued 2019-02-08
dc.identifier.citation Ryan, P.M., Stolte, E.H., London, L.E., Wells, J.M., Long, S.L., Joyce, S.A., Gahan, C.G., Fitzgerald, G.F., Ross, R.P., Caplice, N.M. and Stanton, C. (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC microbiology, 19(1), 33. (13 pp.). DOI:10.1186/s12866-019-1403-0 en
dc.identifier.volume 19 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 13 en
dc.identifier.uri http://hdl.handle.net/10468/9237
dc.identifier.doi 10.1186/s12866-019-1403-0 en
dc.description.abstract Lactobacillus mucosae DPC 6426 has previously demonstrated potentially cardio-protective properties, in the form of dyslipidaemia and hypercholesterolemia correction in an apolipoprotein-E deficient mouse model. This study aims to characterise the manner in which this microbe may modulate host bile pool composition and immune response, in the context of cardiovascular disease. Lactobacillus mucosae DPC 6426 was assessed for bile salt hydrolase activity and specificity. The microbe was compared against several other enteric strains of the same species, as well as a confirmed bile salt hydrolase-active strain, Lactobacillus reuteri APC 2587. en
dc.description.sponsorship Enterprise Ireland Commercialisation Fund (grant number CF/2013/3030A/B); Teagasc (Walsh Fellowship Scheme) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMC part of Springer Nature en
dc.relation.uri https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-019-1403-0
dc.rights © The Author(s). 2019 en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Exopolysaccharide en
dc.subject Bile acid en
dc.subject Bile salt hydrolase (BSH) en
dc.subject Hypercholesterolaemia en
dc.subject CVD en
dc.title Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Catherine Stanton, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: catherine.stanton@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Teagasc en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Microbiology en
dc.internal.IRISemailaddress catherine.stanton@ucc.ie en
dc.identifier.articleid 33 en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/289517/EU/Dietary Fibers supporting Gut and Immune Function - From polysaccharide compound to health claim/FIBEBIOTICS en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.identifier.eissn 1471-2180


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© The Author(s). 2019 Except where otherwise noted, this item's license is described as © The Author(s). 2019
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