PICADAR: A diagnostic predictive tool for primary ciliary dyskinesia

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dc.contributor.author Behan, Laura
dc.contributor.author Dimitrov, Borislav D.
dc.contributor.author Kuehni, Claudia E.
dc.contributor.author Hogg, Claire
dc.contributor.author Carroll, Mary
dc.contributor.author Evans, Hazel J.
dc.contributor.author Goutaki, Myrofora
dc.contributor.author Harris, Amanda
dc.contributor.author Packham, Samantha
dc.contributor.author Walker, Woolf T.
dc.contributor.author Lucas, Jane S.
dc.date.accessioned 2019-11-27T10:02:28Z
dc.date.available 2019-11-27T10:02:28Z
dc.date.issued 2016-04-01
dc.identifier.citation Behan, L., Dimitrov, B. D., Kuehni, C. E., Hogg, C., Carroll, M., Evans, H. J., Goutaki, M., Harris, A., Packham, S., Walker, W. T. and Lucas, J. S. (2016) 'PICADAR: a diagnostic predictive tool for primary ciliary dyskinesia', European Respiratory Journal, 47(4), pp. 1103-1112. doi: 10.1183/13993003.01551-2015 en
dc.identifier.volume 47 en
dc.identifier.issued 4 en
dc.identifier.startpage 1103 en
dc.identifier.endpage 1112 en
dc.identifier.issn 0903-1936
dc.identifier.uri http://hdl.handle.net/10468/9261
dc.identifier.doi 10.1183/13993003.01551-2015 en
dc.description.abstract Symptoms of primary ciliary dyskinesia (PCD) are nonspecific and guidance on whom to refer for testing is limited. Diagnostic tests for PCD are highly specialised, requiring expensive equipment and experienced PCD scientists. This study aims to develop a practical clinical diagnostic tool to identify patients requiring testing. Patients consecutively referred for testing were studied. Information readily obtained from patient history was correlated with diagnostic outcome. Using logistic regression, the predictive performance of the best model was tested by receiver operating characteristic curve analyses. The model was simplified into a practical tool (PICADAR) and externally validated in a second diagnostic centre. Of 641 referrals with a definitive diagnostic outcome, 75 (12%) were positive. PICADAR applies to patients with persistent wet cough and has seven predictive parameters: full-term gestation, neonatal chest symptoms, neonatal intensive care admittance, chronic rhinitis, ear symptoms, situs inversus and congenital cardiac defect. Sensitivity and specificity of the tool were 0.90 and 0.75 for a cut-off score of 5 points. Area under the curve for the internally and externally validated tool was 0.91 and 0.87, respectively. PICADAR represents a simple diagnostic clinical prediction rule with good accuracy and validity, ready for testing in respiratory centres referring to PCD centres. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher European Respiratory Society en
dc.rights © 2016, ERS. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. en
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject PICADAR en
dc.subject Primary ciliary dyskinesia (PCD) en
dc.subject Diagnostic predictive tool en
dc.title PICADAR: A diagnostic predictive tool for primary ciliary dyskinesia en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Laura Behan, Applied Psychology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Heart of England NHS Foundation Trust en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder European Commission en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder Wellcome Trust en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Respiratory Journal en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/305404/EU/Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia/BESTCILIA en
dc.identifier.eissn 1399-3003


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© 2016, ERS. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. Except where otherwise noted, this item's license is described as © 2016, ERS. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
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