Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications

Show simple item record

dc.contributor.author Leemaqz, Shalem Y.
dc.contributor.author Dekker, Gustaaf A.
dc.contributor.author McCowan, Lesley M.
dc.contributor.author Kenny, Louise C.
dc.contributor.author Myers, Jenny E.
dc.contributor.author Simpson, Nigel A. B.
dc.contributor.author Poston, Lucilla
dc.contributor.author Roberts, Claire T.
dc.date.accessioned 2019-11-27T11:45:33Z
dc.date.available 2019-11-27T11:45:33Z
dc.date.issued 2016-04-30
dc.identifier.citation Leemaqz, S. Y., Dekker, G. A., McCowan, L. M., Kenny, L. C., Myers, J. E., Simpson, N. A. B., Poston, L. and Roberts, C. T. (2016) 'Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications', Reproductive Toxicology, 62, pp. 77-86. doi: 10.1016/j.reprotox.2016.04.021 en
dc.identifier.volume 62 en
dc.identifier.startpage 77 en
dc.identifier.endpage 86 en
dc.identifier.issn 0890-6238
dc.identifier.uri http://hdl.handle.net/10468/9266
dc.identifier.doi 10.1016/j.reprotox.2016.04.021 en
dc.description.abstract Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15 ± 1 and 20 ± 1 weeks’ gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks’ gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45–3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41–3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks’ gestation had a greater effect size [adj OR 5.44 (95% CI 2.44–12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern. en
dc.description.sponsorship National Health and Medical Research Council (GNT1020749, GNT519225); Health Research Council [04/198]; Health Research Board of Ireland [CSA/2007/2]; National Health Service NEAT Grant [Neat Grant FSD025]; Biotechnology and Biological Sciences Research council [GT084] en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights ©2016 The Author(s). Published by Elsevier Inc. Under a Creative Commons license en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Marijuana en
dc.subject Smoking en
dc.subject BMI en
dc.subject Pregnancy outcome en
dc.subject Spontaneous preterm birth en
dc.title Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Louise Kenny,The Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland. +353-21-490-3000 Email:l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Foundation for Research, Science and Technology en
dc.contributor.funder National Health and Medical Research Council en
dc.contributor.funder Evelyn Bond Fund en
dc.contributor.funder Auckland District Health Board Charitable Trust en
dc.contributor.funder Health Research Board en
dc.contributor.funder Oxford University Hospitals NHS Foundation Trust en
dc.contributor.funder Biotechnology and Biological Sciences Research Council en
dc.contributor.funder University of Manchester en
dc.contributor.funder King’s College London en
dc.contributor.funder University of Leeds en
dc.contributor.funder New Enterprise Research Fund en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Reproductive Toxicology en
dc.internal.IRISemailaddress l.kenny@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.identifier.eissn 1873-1708


Files in this item

This item appears in the following Collection(s)

Show simple item record

©2016 The Author(s). Published by Elsevier Inc. Under a Creative Commons license Except where otherwise noted, this item's license is described as ©2016 The Author(s). Published by Elsevier Inc. Under a Creative Commons license
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement