Composition and temporal stability of the gut microbiota in older persons

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dc.contributor.author Jeffery, Ian B.
dc.contributor.author Lynch, Denise B.
dc.contributor.author O'Toole, Paul W.
dc.date.accessioned 2019-11-27T12:55:18Z
dc.date.available 2019-11-27T12:55:18Z
dc.date.issued 2015-06-19
dc.identifier.citation Jeffery, I. B., Lynch, D. B. and O'Toole, P. W. (2016) 'Composition and temporal stability of the gut microbiota in older persons', The ISME Journal, 10(1), pp. 170-182. doi: 10.1038/ismej.2015.88 en
dc.identifier.volume 10 en
dc.identifier.startpage 170 en
dc.identifier.endpage 182 en
dc.identifier.issn 1751-7362
dc.identifier.uri http://hdl.handle.net/10468/9269
dc.identifier.doi 10.1038/ismej.2015.88 en
dc.description.abstract The composition and function of the human gut microbiota has been linked to health and disease. We previously identified correlations between habitual diet, microbiota composition gradients and health gradients in an unstratified cohort of 178 elderly subjects. To refine our understanding of diet–microbiota associations and differential taxon abundance, we adapted an iterative bi-clustering algorithm (iterative binary bclustering of gene sets (iBBiG)) and applied it to microbiota composition data from 732 faecal samples from 371 ELDERMET cohort subjects, including longitudinal samples. We thus identified distinctive microbiota configurations associated with ageing in both community and long-stay residential care elderly subjects. Mixed-taxa populations were identified that had clinically distinct associations. Microbiota temporal instability was observed in both community-dwelling and long-term care subjects, particularly in those with low initial microbiota diversity. However, the stability of the microbiota of subjects had little impact on the directional change of the microbiota as observed for long-stay subjects who display a gradual shift away from their initial microbiota. This was not observed in community-dwelling subjects. This directional change was associated with duration in long-stay. Changes in these bacterial populations represent the loss of the health-associated and youth-associated microbiota components and gain of an elderly associated microbiota. Interestingly, community-associated microbiota configurations were impacted more by the use of antibiotics than the microbiota of individuals in long-term care, as the community-associated microbiota showed more loss but also more recovery following antibiotic treatment. This improved definition of gut microbiota composition patterns in the elderly will better inform the design of dietary or antibiotic interventions targeting the gut microbiota. en
dc.description.sponsorship Health Research Board FHRI award to the ELDERMET project (07/FHRI/UCC/3) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Nature Research en
dc.rights © The Author(s) 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/ en
dc.subject Microbial ecology en
dc.subject Public health en
dc.subject Temporal stability en
dc.subject Gut microbiota en
dc.title Composition and temporal stability of the gut microbiota in older persons en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul O Toole, School of Mircrobiology and APC , University College Cork, Cork, Ireland. +353-21-490-3000 Email:pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Health Research Board en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder General Mills Inc en
dc.description.status Peer reviewed en
dc.identifier.journaltitle ISME Journal en
dc.internal.IRISemailaddress pwotoole@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/ en
dc.identifier.eissn 1751-7370


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© The Author(s) 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ Except where otherwise noted, this item's license is described as © The Author(s) 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
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